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Spg7 SPG7 matrix AAA peptidase subunit, paraplegin [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101704059, updated on 1-Mar-2025
Gene symbol
Spg7
Gene description
SPG7 matrix AAA peptidase subunit, paraplegin
See related
Ensembl:ENSHGLG00000012312 RGD:18912194
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
all
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Try the new Transcripts and proteins table
See Spg7 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
17
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624746.1 (344754..377939, complement)

NW_004624746.1Genomic Context describing neighboring genes Neighboring gene dipeptidase 1 Neighboring gene ribosomal protein L13 Neighboring gene ankyrin repeat domain containing 11 Neighboring gene transmembrane protein 56 pseudogene Neighboring gene uncharacterized LOC106009237

Genomic Sequence:
NW_004624746 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of m-AAA complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
paraplegin
Names
SPG7, paraplegin matrix AAA peptidase subunit

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624746.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    344754..377939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004842642.3 → XP_004842699.1  paraplegin isoform X3

    UniProtKB/TrEMBL
    A0AAX6P346, G5API4
    Conserved Domains (5) summary
    TIGR01241
    Location:262 → 687
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:343 → 418
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:500 → 685
    Peptidase_M41; Peptidase family M41
    pfam06480
    Location:142 → 239
    FtsH_ext; FtsH Extracellular
    cl21455
    Location:305 → 361
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_004842640.3 → XP_004842697.1  paraplegin isoform X1

    UniProtKB/TrEMBL
    A0AAX6P3A7, G5API4
    Conserved Domains (5) summary
    TIGR01241
    Location:262 → 745
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:343 → 476
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:558 → 743
    Peptidase_M41; Peptidase family M41
    pfam06480
    Location:142 → 239
    FtsH_ext; FtsH Extracellular
    cl21455
    Location:305 → 361
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_004842641.3 → XP_004842698.1  paraplegin isoform X2

    UniProtKB/TrEMBL
    A0AAX6P2Y2, G5API4
    Related
    ENSHGLP00000017192.1, ENSHGLT00000017365.1
    Conserved Domains (5) summary
    TIGR01241
    Location:260 → 743
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:341 → 474
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:556 → 741
    Peptidase_M41; Peptidase family M41
    pfam06480
    Location:140 → 237
    FtsH_ext; FtsH Extracellular
    cl21455
    Location:303 → 359
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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