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Nae1 NEDD8 activating enzyme E1 subunit 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101700870, updated on 1-Mar-2025
Gene symbol
Nae1
Gene description
NEDD8 activating enzyme E1 subunit 1
See related
Ensembl:ENSHGLG00000018813 RGD:18930233
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
all
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See Nae1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624746.1 (19648365..19687884)

NW_004624746.1Genomic Context describing neighboring genes Neighboring gene cadherin 16 Neighboring gene pyruvate dehyrogenase phosphatase catalytic subunit 2 Neighboring gene carbonic anhydrase 7 Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene dynein cytoplasmic 1 light intermediate chain 2

Genomic Sequence:
NW_004624746 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NEDD8 activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
NEDD8-activating enzyme E1 regulatory subunit

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624746.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    19648365..19687884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004843095.2 → XP_004843152.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    See identical proteins and their annotated locations for XP_004843152.1

    UniProtKB/TrEMBL
    A0AAX6SV55, G5BDH2
    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    cl25380
    Location:321 → 424
    ThiF; ThiF family

  2. XM_004843093.3 → XP_004843150.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

    UniProtKB/TrEMBL
    A0A0P6JHS4, G5BDH2
    Related
    ENSHGLP00000026440.1, ENSHGLT00000026676.1
    Conserved Domains (2) summary
    COG0476
    Location:9 → 192
    ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
    cd01493
    Location:11 → 532
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

  3. XM_004843094.3 → XP_004843151.1  NEDD8-activating enzyme E1 regulatory subunit isoform X2

    UniProtKB/TrEMBL
    A0AAX6P474, G5BDH2
    Conserved Domains (2) summary
    COG0476
    Location:9 → 192
    ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
    cd01493
    Location:11 → 511
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

  4. XM_021256935.1 → XP_021112594.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    UniProtKB/TrEMBL
    A0AAX6SV55, G5BDH2
    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    cl25380
    Location:321 → 424
    ThiF; ThiF family

  5. XM_004843096.3 → XP_004843153.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    See identical proteins and their annotated locations for XP_004843153.1

    UniProtKB/TrEMBL
    A0AAX6SV55, G5BDH2
    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    cl25380
    Location:321 → 424
    ThiF; ThiF family
Nucleotide Protein
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