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Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101700245, updated on 8-Mar-2024

Summary

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Gene symbol
Arhgef6
Gene description
Rac/Cdc42 guanine nucleotide exchange factor 6
Locus tag
GW7_08734
See related
Ensembl:ENSHGLG00000004195
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624808.1 (10320388..10464081)

NW_004624808.1Genomic Context describing neighboring genes Neighboring gene cAMP-regulated phosphoprotein 19 pseudogene Neighboring gene RNA binding motif protein X-linked Neighboring gene CD40 ligand Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624808 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 6
Names
Rho guanine nucleotide exchange factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624808.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    10320388..10464081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013078686.2 → XP_012934140.1  rho guanine nucleotide exchange factor 6 isoform X1

    Related
    ENSHGLP00000005738.1, ENSHGLT00000005810.1
    Conserved Domains (8) summary
    cd12060
    Location:162 → 218
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5 → 105
    CH; Calponin homology domain
    cd00160
    Location:242 → 419
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:450 → 547
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:467 → 548
    PH; PH domain
    pfam16523
    Location:677 → 763
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:573 → 674
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  2. XM_013078689.2 → XP_012934143.1  rho guanine nucleotide exchange factor 6 isoform X2

    Conserved Domains (6) summary
    cd12060
    Location:8 → 64
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:88 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 393
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:313 → 394
    PH; PH domain
    pfam16523
    Location:523 → 609
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:419 → 520
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
Nucleotide Protein
Heading Accession and Version

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