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Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101699656, updated on 1-Mar-2025
Gene symbol
Phlpp2
Gene description
PH domain and leucine rich repeat protein phosphatase 2
See related
Ensembl:ENSHGLG00000012919 RGD:18911061
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
all
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Try the new Transcripts and proteins table
See Phlpp2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
20
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624746.1 (13917070..13994212, complement)

NW_004624746.1Genomic Context describing neighboring genes Neighboring gene tyrosine aminotransferase Neighboring gene MARVEL domain containing 3 Neighboring gene up-regulated during skeletal muscle growth protein 5 Neighboring gene adaptor related protein complex 1 subunit gamma 1 Neighboring gene CD63 antigen pseudogene

Genomic Sequence:
NW_004624746 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
PH domain leucine-rich repeat-containing protein phosphatase 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624746.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    13917070..13994212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004842901.2 → XP_004842958.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2

    UniProtKB/TrEMBL
    A0AAX6P3Q9, G5BNU2
    Related
    ENSHGLP00000018077.1, ENSHGLT00000018254.1
    Conserved Domains (6) summary
    cd00116
    Location:347 → 640
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00143
    Location:818 → 1067
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    cd13322
    Location:183 → 277
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:496 → 515
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:678 → 719
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:678 → 737
    LRR_8; Leucine rich repeat

  2. XM_021256735.1 → XP_021112394.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1

    UniProtKB/TrEMBL
    A0AAX6SV76, G5BNU2
    Conserved Domains (4) summary
    cd00143
    Location:819 → 1068
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    cd13322
    Location:184 → 278
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:497 → 516
    LRR_RI; leucine-rich repeat [structural motif]
    cl26793
    Location:286 → 761
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  3. XM_021256737.1 → XP_021112396.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X3

    UniProtKB/TrEMBL
    A0AAX6SRS8, G5BNU2
    Related
    ENSHGLP00000018078.1, ENSHGLT00000018255.1
    Conserved Domains (4) summary
    cd00143
    Location:789 → 1038
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    cd13322
    Location:154 → 248
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:467 → 486
    LRR_RI; leucine-rich repeat [structural motif]
    cl26793
    Location:256 → 731
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
Nucleotide Protein
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