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SERF2 small EDRK-rich factor 2 [ Homo sapiens (human) ]

Gene ID: 10169, updated on 24-Nov-2020

Summary

Official Symbol
SERF2provided by HGNC
Official Full Name
small EDRK-rich factor 2provided by HGNC
Primary source
HGNC:HGNC:10757
See related
Ensembl:ENSG00000140264 MIM:605054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM2C; 4F5REL; H4F5REL; HsT17089
Expression
Ubiquitous expression in prostate (RPKM 57.5), colon (RPKM 53.4) and 25 other tissues See more
Orthologs

Genomic context

See SERF2 in Genome Data Viewer
Location:
15q15.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43777086..43796089)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44069294..44088287)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated 2 pseudogene 1 Neighboring gene protein disulfide isomerase family A member 3 Neighboring gene elongation factor for RNA polymerase II 3 Neighboring gene SERF2-C15orf63 readthrough Neighboring gene microRNA 1282 Neighboring gene serine incorporator 4 Neighboring gene huntingtin interacting protein K Neighboring gene microfibril associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20431, FLJ37527, FLJ38557, MGC48826

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
small EDRK-rich factor 2
Names
gastric cancer-related protein VRG107
protein 4F5-related

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018108.4NP_001018118.1  small EDRK-rich factor 2 isoform c

    See identical proteins and their annotated locations for NP_001018118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AC018512, BC008214, BM970646
    Consensus CDS
    CCDS32218.1
    UniProtKB/Swiss-Prot
    P84101
    Related
    ENSP00000249786.4, ENST00000249786.8
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  2. NM_001199875.1NP_001186804.1  small EDRK-rich factor 2 isoform a

    See identical proteins and their annotated locations for NP_001186804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC018512, AK307547, BC009869, BM970646
    Consensus CDS
    CCDS55963.1
    UniProtKB/Swiss-Prot
    P84101
    Related
    ENSP00000387187.2, ENST00000409960.6
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  3. NM_001199876.1NP_001186805.1  small EDRK-rich factor 2 isoform b

    See identical proteins and their annotated locations for NP_001186805.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC018512, BC009869, BM970646, BP317864
    Consensus CDS
    CCDS55964.1
    UniProtKB/Swiss-Prot
    P84101
    Related
    ENSP00000339647.5, ENST00000339624.9
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  4. NM_001199877.2NP_001186806.1  small EDRK-rich factor 2 isoform c

    See identical proteins and their annotated locations for NP_001186806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AC018512, BC009869, BM970646, BQ061048
    Consensus CDS
    CCDS32218.1
    UniProtKB/Swiss-Prot
    P84101
    Related
    ENSP00000370764.1, ENST00000381359.5
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  5. NM_001199878.2NP_001186807.1  small EDRK-rich factor 2 isoform d

    See identical proteins and their annotated locations for NP_001186807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC018512, BI260545, BM970646, DA302996
    Consensus CDS
    CCDS55965.1
    UniProtKB/Swiss-Prot
    P84101
    Related
    ENSP00000384300.1, ENST00000403425.5

RNA

  1. NR_037672.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and lacks a segment of the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018512, BC009869, BM970646, DB060650

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43777086..43796089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005770.5: Suppressed sequence

    Description
    NM_005770.5: This RefSeq was permanently suppressed because it contains the wrong CDS.
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