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Nlrp6 NLR family, pyrin domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 101613, updated on 20-Feb-2024

Summary

Official Symbol
Nlrp6provided by MGI
Official Full Name
NLR family, pyrin domain containing 6provided by MGI
Primary source
MGI:MGI:2141990
See related
Ensembl:ENSMUSG00000038745 AllianceGenome:MGI:2141990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Avr; Navr; Nalp6; Pypaf5; Non-AVR; Navr/Avr
Summary
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]
Expression
Biased expression in large intestine adult (RPKM 52.0), liver adult (RPKM 39.5) and 7 other tissues See more
Orthologs
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Genomic context

See Nlrp6 in Genome Data Viewer
Location:
7 F5; 7 86.14 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140500777..140509105)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140920902..140929192)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 8B Neighboring gene STARR-positive B cell enhancer ABC_E8220 Neighboring gene cDNA sequence BC023486 Neighboring gene STARR-positive B cell enhancer ABC_E2853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148127673-148127984 Neighboring gene protein glucosylgalactosylhydroxylysine glucosidase Neighboring gene interferon induced transmembrane protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipoteichoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables vasopressin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vasopressin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NLRP6 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in NLRP6 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in acute inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in host-mediated regulation of intestinal microbiota composition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in host-mediated regulation of intestinal microbiota composition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-18 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil-mediated killing of gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-18-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-18-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-18-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NLRP6 inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NLRP6 inflammasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of canonical inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of canonical inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in non-membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in non-membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NACHT, LRR and PYD domains-containing protein 6
Names
NACHT, leucine rich repeat and PYD containing 6
NACHT/LRR/pyrin domain-containing protein 6
PYRIN-containing APAF1-like protein 5
angiotensin II/vasopressin receptor
non-angiotensin-vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133946.3NP_598707.2  NACHT, LRR and PYD domains-containing protein 6

    See identical proteins and their annotated locations for NP_598707.2

    Status: VALIDATED

    Source sequence(s)
    AC107815, AC162287
    Consensus CDS
    CCDS40178.2
    UniProtKB/Swiss-Prot
    C9W978, F8UKQ6, Q67EY0, Q8K0L4, Q91WS2
    UniProtKB/TrEMBL
    E9QNS0
    Related
    ENSMUSP00000139357.2, ENSMUST00000183845.8
    Conserved Domains (3) summary
    cd00116
    Location:617863
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08321
    Location:1696
    Pyrin_ASC-like; Pyrin Death Domain found in ASC
    pfam05729
    Location:195348
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140500777..140509105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081389.1: Suppressed sequence

    Description
    NM_001081389.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.