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Grwd1 glutamate-rich WD repeat containing 1 [ Mus musculus (house mouse) ]

Gene ID: 101612, updated on 6-Jun-2024

Summary

Official Symbol
Grwd1provided by MGI
Official Full Name
glutamate-rich WD repeat containing 1provided by MGI
Primary source
MGI:MGI:2141989
See related
Ensembl:ENSMUSG00000053801 AllianceGenome:MGI:2141989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A301; Grwd; Wdr28
Summary
Predicted to enable DNA replication origin binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in DNA replication; nucleosome assembly; and nucleosome disassembly. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in embryo. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.6), limb E14.5 (RPKM 9.3) and 28 other tissues See more
Orthologs
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Genomic context

See Grwd1 in Genome Data Viewer
Location:
7 B3; 7 29.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45474647..45480218, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45825223..45830994, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lemur tyrosine kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E549 Neighboring gene cytohesin 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene predicted gene 45441 Neighboring gene glutamate receptor, ionotropic, NMDA2D (epsilon 4) Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate-rich WD repeat-containing protein 1
Names
glutamate rich WD repeat protein GRWD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420248.1NP_001407177.1  glutamate-rich WD repeat-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149053
    UniProtKB/TrEMBL
    Q8K335
  2. NM_001420249.1NP_001407178.1  glutamate-rich WD repeat-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC149053
    UniProtKB/TrEMBL
    Q8BIF7
  3. NM_001420250.1NP_001407179.1  glutamate-rich WD repeat-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC149053
    UniProtKB/TrEMBL
    Q8BIF7
  4. NM_153419.2NP_700468.2  glutamate-rich WD repeat-containing protein 1

    See identical proteins and their annotated locations for NP_700468.2

    Status: VALIDATED

    Source sequence(s)
    BC083143, BQ886252, DT904438
    Consensus CDS
    CCDS21266.2
    UniProtKB/Swiss-Prot
    G3UVT6, Q810D6, Q922H3
    UniProtKB/TrEMBL
    Q5XJZ3
    Related
    ENSMUSP00000103351.3, ENSMUST00000107723.9
    Conserved Domains (4) summary
    COG2319
    Location:194383
    WD40; WD40 repeat [General function prediction only]
    pfam12265
    Location:44111
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    sd00039
    Location:218259
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:206384
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45474647..45480218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)