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LPAR6 lysophosphatidic acid receptor 6 [ Homo sapiens (human) ]

Gene ID: 10161, updated on 29-Mar-2023

Summary

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Official Symbol
LPAR6provided by HGNC
Official Full Name
lysophosphatidic acid receptor 6provided by HGNC
Primary source
HGNC:HGNC:15520
See related
Ensembl:ENSG00000139679 MIM:609239; AllianceGenome:HGNC:15520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5
Summary
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues See more
Orthologs
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Genomic context

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See LPAR6 in Genome Data Viewer
Location:
13q14.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (48389571..48444669, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (47609888..47664937, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48985274..49018805, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor 1 Neighboring gene PEST containing nuclear protein pseudogene 5 Neighboring gene uncharacterized LOC112268118 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:48985733-48986234 Neighboring gene uncharacterized LOC124903173 Neighboring gene RCC1 and BTB domain containing protein 2 Neighboring gene uncharacterized LOC124903174

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis. Yanagida K, et al. Hum Mol Genet, 2023 Feb 19. PMID 36173926
  2. Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma. He J, et al. Int J Environ Res Public Health, 2021 Oct 20. PMID 34769557, Free PMC Article
  3. Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene. Piquer-García J, et al. Int J Dermatol, 2021 Feb. PMID 33017051
  4. A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells. Lippolis R, et al. Biochem Biophys Res Commun, 2020 Jun 11. PMID 32321639
  5. Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families. Khan GM, et al. Int J Dermatol, 2019 Aug. PMID 31077348

See all (52) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis.
    Title: Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis.
  2. Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma.
    Title: Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma.
  3. Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene.
    Title: Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene.
  4. A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells.
    Title: A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells.
  5. A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator.
    Title: A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator.
  6. Study revealed a novel homozygous missense mutation c.47A>T (p.Lys16Met) in the LPAR6 gene in Pakistani family with autosomal recessive wooly hair/hypotrichosis.
    Title: Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families.
  7. LPAR6 was downregulated in breast cancer(BC), and low LPAR6 expression was related to poor prognosis. The anti-tumor drug 5-Aza significantly upregulated LPAR6 expression in vitro, and LPAR6 might act as a tumor suppressor in BC.
    Title: Lysophosphatidic Acid Receptor 6 (LPAR6) Expression and Prospective Signaling Pathway Analysis in Breast Cancer.
  8. mRNA expression analyses revealed that ADSCs and MES largely expressed LPA receptor 1 (LPAR1) while epithelial cells mainly expressed LPAR6. LPA 18:1 activated all the cell populations and cell lines by rise in cytosolic free calcium concentrations. MES and ADSCs expressed ATX whereas epithelial cells did not.
    Title: ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
  9. Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in three consanguineous Pakistani families.
    Title: Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in consanguineous families.
  10. DLD-C-F cells formed large-sized colonies, but not DLD-F-C cells, correlating with LPAR1 and LPAR6 gene expression levels. These results suggest that LPA1 and LPA6 may regulate the colony formation activity in DLD1 cells treated with anticancer drugs.
    Title: Effects of LPA(1) and LPA(6) on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hypotrichosis 8
MedGen: C3279470 OMIM: 278150 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC120358

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysophosphatidic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
lysophosphatidic acid receptor 6
Names
G-protein coupled purinergic receptor P2Y5
LPA receptor 6
P2Y purinoceptor 5
RB intron encoded G-protein coupled receptor
oleoyl-L-alpha-lysophosphatidic acid receptor
purinergic receptor 5
purinergic receptor P2Y G protein-coupled protein 5
purinergic receptor P2Y, G-protein coupled, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012874.2 RefSeqGene

    Range
    36556..38531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001162497.3 → NP_001155969.1  lysophosphatidic acid receptor 6

    See identical proteins and their annotated locations for NP_001155969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    P43657, Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2, B3KVQ5
    Related
    ENSP00000344353.2, ENST00000345941.2
    Conserved Domains (1) summary
    cd15156
    Location:18 → 302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001162498.3 → NP_001155970.1  lysophosphatidic acid receptor 6

    See identical proteins and their annotated locations for NP_001155970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    P43657, Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2, B3KVQ5
    Related
    ENSP00000482660.1, ENST00000620633.5
    Conserved Domains (1) summary
    cd15156
    Location:18 → 302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001377316.2 → NP_001364245.1  lysophosphatidic acid receptor 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2
    Conserved Domains (1) summary
    cd15156
    Location:18 → 302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001377317.2 → NP_001364246.1  lysophosphatidic acid receptor 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2
    Conserved Domains (1) summary
    cd15156
    Location:18 → 302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_005767.7 → NP_005758.2  lysophosphatidic acid receptor 6

    See identical proteins and their annotated locations for NP_005758.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    P43657, Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2, B3KVQ5
    Related
    ENSP00000367691.3, ENST00000378434.8
    Conserved Domains (1) summary
    cd15156
    Location:18 → 302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    48389571..48444669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430024.1 → XP_047285980.1  lysophosphatidic acid receptor 6 isoform X3

  2. XM_047430023.1 → XP_047285979.1  lysophosphatidic acid receptor 6 isoform X2

  3. XM_047430021.1 → XP_047285977.1  lysophosphatidic acid receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2

  4. XM_047430019.1 → XP_047285975.1  lysophosphatidic acid receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2

  5. XM_047430022.1 → XP_047285978.1  lysophosphatidic acid receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2

  6. XM_047430020.1 → XP_047285976.1  lysophosphatidic acid receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z3S6
    UniProtKB/TrEMBL
    A0A024RDT2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    47609888..47664937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373988.1 → XP_054229963.1  lysophosphatidic acid receptor 6 isoform X3

  2. XM_054373987.1 → XP_054229962.1  lysophosphatidic acid receptor 6 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43657.3 GenPept UniProtKB/Swiss-Prot:P43657

Gene LinkOut

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