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LPAR6 lysophosphatidic acid receptor 6 [ Homo sapiens (human) ]

Gene ID: 10161, updated on 8-Jul-2021

Summary

Official Symbol
LPAR6provided by HGNC
Official Full Name
lysophosphatidic acid receptor 6provided by HGNC
Primary source
HGNC:HGNC:15520
See related
Ensembl:ENSG00000139679 MIM:609239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5
Summary
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues See more
Orthologs
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Genomic context

See LPAR6 in Genome Data Viewer
Location:
13q14.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (48400897..48444669, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48985274..49018805, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor 1 Neighboring gene PEST containing nuclear protein pseudogene 5 Neighboring gene uncharacterized LOC112268118 Neighboring gene RCC1 and BTB domain containing protein 2 Neighboring gene long intergenic non-protein coding RNA 1077 Neighboring gene long intergenic non-protein coding RNA 462

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120358

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysophosphatidic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lysophosphatidic acid receptor 6
Names
G-protein coupled purinergic receptor P2Y5
LPA receptor 6
P2Y purinoceptor 5
RB intron encoded G-protein coupled receptor
oleoyl-L-alpha-lysophosphatidic acid receptor
purinergic receptor 5
purinergic receptor P2Y G protein-coupled protein 5
purinergic receptor P2Y, G-protein coupled, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012874.1 RefSeqGene

    Range
    5036..38660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001162497.3NP_001155969.1  lysophosphatidic acid receptor 6

    See identical proteins and their annotated locations for NP_001155969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    P43657
    UniProtKB/TrEMBL
    A0A024RDT2, B3KVQ5
    Related
    ENSP00000344353.2, ENST00000345941.2
    Conserved Domains (1) summary
    cd15156
    Location:18302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001162498.3NP_001155970.1  lysophosphatidic acid receptor 6

    See identical proteins and their annotated locations for NP_001155970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    P43657
    UniProtKB/TrEMBL
    A0A024RDT2, B3KVQ5
    Related
    ENSP00000482660.1, ENST00000620633.5
    Conserved Domains (1) summary
    cd15156
    Location:18302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001377316.2NP_001364245.1  lysophosphatidic acid receptor 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Conserved Domains (1) summary
    cd15156
    Location:18302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001377317.2NP_001364246.1  lysophosphatidic acid receptor 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Conserved Domains (1) summary
    cd15156
    Location:18302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_005767.7NP_005758.2  lysophosphatidic acid receptor 6

    See identical proteins and their annotated locations for NP_005758.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AL136960, AL392048
    Consensus CDS
    CCDS9410.1
    UniProtKB/Swiss-Prot
    P43657
    UniProtKB/TrEMBL
    A0A024RDT2, B3KVQ5
    Related
    ENSP00000367691.3, ENST00000378434.8
    Conserved Domains (1) summary
    cd15156
    Location:18302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    48400897..48444669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449304.1XP_024305072.1  lysophosphatidic acid receptor 6 isoform X3

  2. XM_024449303.1XP_024305071.1  lysophosphatidic acid receptor 6 isoform X2

  3. XM_024449302.1XP_024305070.1  lysophosphatidic acid receptor 6 isoform X1

    Conserved Domains (1) summary
    cd15156
    Location:18302
    7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
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