Format

Send to:

Choose Destination

CDH18 cadherin 18 [ Homo sapiens (human) ]

Gene ID: 1016, updated on 2-Oct-2018

Summary

Official Symbol
CDH18provided by HGNC
Official Full Name
cadherin 18provided by HGNC
Primary source
HGNC:HGNC:1757
See related
Ensembl:ENSG00000145526 MIM:603019; Vega:OTTHUMG00000090578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDH14; CDH24; CDH14L
Summary
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Expression
Biased expression in brain (RPKM 4.0), adrenal (RPKM 1.3) and 1 other tissue See more
Orthologs

Genomic context

See CDH18 in Genome Data Viewer
Location:
5p14.3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (19471296..20575886, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (19473140..20575972, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene 14 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 15 Neighboring gene uncharacterized LOC105374672 Neighboring gene CDH18 antisense RNA 1 Neighboring gene nucleoporin 50 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 2241 Neighboring gene long intergenic non-protein coding RNA 2146 Neighboring gene uncharacterized LOC112267938

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
NHGRI GWA Catalog
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
NHGRI GWA Catalog
Genome-wide association scan of trait depression.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
    Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction organization TAS
Traceable Author Statement
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cadherin-18
Names
cadherin 18, type 2
cadherin-14
cadherin-like 24
ey-cadherin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167667.2NP_001161139.1  cadherin-18 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Variant 2 and 9 encode the same protein (isoform 2). This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC025173, AC118463, AK295087, CR747663, DA132038, DA368944, U59325
    Consensus CDS
    CCDS54835.1
    UniProtKB/Swiss-Prot
    Q13634
    Related
    ENSP00000422138.1, OTTHUMP00000220999, ENST00000502796.5, OTTHUMT00000366745
    Conserved Domains (2) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
  2. NM_001291956.2NP_001278885.1  cadherin-18 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001278885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 5, 6, and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AC025173, AC118463, AK289547, CR747663, DA132038, DC310391, U59325
    Consensus CDS
    CCDS3889.1
    UniProtKB/Swiss-Prot
    Q13634
    Related
    ENSP00000425093.1, OTTHUMP00000221001, ENST00000507958.5, OTTHUMT00000366747
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  3. NM_001291957.2NP_001278886.1  cadherin-18 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001278886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1. Variant 4 and 8 encode the same protein (isoform 3). This isoform (3) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC025173, AC118463, AK295087, AK308745, BC031051, CA425592, CR747663, DA132038
    Consensus CDS
    CCDS75229.1
    UniProtKB/TrEMBL
    D6RER2
    Related
    ENSP00000424931.1, OTTHUMP00000221000, ENST00000506372.5, OTTHUMT00000366746
    Conserved Domains (2) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
  4. NM_001349556.1NP_001336485.1  cadherin-18 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 5, 6, and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AC025173, AC118463, AK289547, CR747663, DA132038, DC310391, U59325
    Consensus CDS
    CCDS3889.1
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  5. NM_001349558.1NP_001336487.1  cadherin-18 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 3, 5, 6, and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AC025173, AC094103, AC118463, AK289547, CR747663, DA132038, DC310391, U59325
    Consensus CDS
    CCDS3889.1
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  6. NM_001349559.1NP_001336488.1  cadherin-18 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 3, 5, 6, and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AC025173, AC118463, BC031051, CR747663, DA132038, DA181710, U59325
    Consensus CDS
    CCDS3889.1
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  7. NM_001349560.1NP_001336489.1  cadherin-18 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1. Variant 4 and 8 encode the same protein (isoform 3). This isoform (3) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC025173, AC118463, AK295087, CK005847, CR747663, DA132038, DA181710, U59325
    Consensus CDS
    CCDS75229.1
    Conserved Domains (2) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
  8. NM_001349561.1NP_001336490.1  cadherin-18 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Variant 2 and 9 encode the same protein (isoform 2). This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC025173, AC118463, AK295087, CR747663, DA132038, DA368944, U59325
    Consensus CDS
    CCDS54835.1
    Conserved Domains (2) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
  9. NM_001349562.1NP_001336491.1  cadherin-18 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 4 which has a shorter N-terminus compared to isoform 1. Variants 11 and 12 encode the same protein (isoform 4).
    Source sequence(s)
    AC025173, AC113397, AC118463, AK289547, CR747663, DA132038, DC310391, DC343148, U59325
    Conserved Domains (3) summary
    cd11304
    Location:164261
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:243
    CA; Cadherin repeats
    pfam01049
    Location:414560
    Cadherin_C; Cadherin cytoplasmic region
  10. NM_001349563.1NP_001336492.1  cadherin-18 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains an alternate exon in the 5' region, which results in the use of a downstream start codon compared to variant 1. It encodes isoform 4 which has a shorter N-terminus compared to isoform 1. Variants 11 and 12 encode the same protein (isoform 4).
    Source sequence(s)
    AC025173, AC113397, AC118463, BC031051, CR747663, DA132038, DA368944, U59325
    Conserved Domains (3) summary
    cd11304
    Location:164261
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:243
    CA; Cadherin repeats
    pfam01049
    Location:414560
    Cadherin_C; Cadherin cytoplasmic region
  11. NM_004934.4NP_004925.1  cadherin-18 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_004925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, 5, 6, and 7 encode the same protein (isoform 1).
    Source sequence(s)
    AC025173, AC118463, BC031051, CR747663, DA132038, DA368944, U59325
    Consensus CDS
    CCDS3889.1
    UniProtKB/Swiss-Prot
    Q13634
    Related
    ENSP00000371710.1, OTTHUMP00000115690, ENST00000382275.5, OTTHUMT00000207117
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    19471296..20575886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513930.3XP_011512232.1  cadherin-18 isoform X4

    See identical proteins and their annotated locations for XP_011512232.1

    UniProtKB/TrEMBL
    D6RER2
    Related
    ENSP00000425854.1, ENST00000511273.1
    Conserved Domains (2) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
  2. XM_011513928.3XP_011512230.1  cadherin-18 isoform X2

    Conserved Domains (3) summary
    cd11304
    Location:321418
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:1391
    CA; Cadherin repeats
    pfam01049
    Location:578716
    Cadherin_C; Cadherin cytoplasmic region
  3. XM_011513929.3XP_011512231.1  cadherin-18 isoform X3

    Conserved Domains (2) summary
    cd11304
    Location:219316
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:476614
    Cadherin_C; Cadherin cytoplasmic region
  4. XM_005248228.4XP_005248285.1  cadherin-18 isoform X1

    See identical proteins and their annotated locations for XP_005248285.1

    UniProtKB/Swiss-Prot
    Q13634
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  5. XM_017008924.2XP_016864413.1  cadherin-18 isoform X1

    UniProtKB/Swiss-Prot
    Q13634
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  6. XM_017008928.2XP_016864417.1  cadherin-18 isoform X1

    UniProtKB/Swiss-Prot
    Q13634
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  7. XM_017008926.2XP_016864415.1  cadherin-18 isoform X1

    UniProtKB/Swiss-Prot
    Q13634
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  8. XM_017008927.2XP_016864416.1  cadherin-18 isoform X1

    UniProtKB/Swiss-Prot
    Q13634
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  9. XM_017008929.2XP_016864418.1  cadherin-18 isoform X1

    UniProtKB/Swiss-Prot
    Q13634
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  10. XM_006714435.4XP_006714498.1  cadherin-18 isoform X1

    See identical proteins and their annotated locations for XP_006714498.1

    UniProtKB/Swiss-Prot
    Q13634
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
  11. XM_017008930.2XP_016864419.1  cadherin-18 isoform X1

    UniProtKB/Swiss-Prot
    Q13634
    Related
    ENSP00000274170.3, ENST00000274170.8
    Conserved Domains (3) summary
    cd11304
    Location:387484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79157
    CA; Cadherin repeats
    pfam01049
    Location:637783
    Cadherin_C; Cadherin cytoplasmic region
Support Center