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ABI2 abl interactor 2 [ Homo sapiens (human) ]

Gene ID: 10152, updated on 11-Sep-2019

Summary

Official Symbol
ABI2provided by HGNC
Official Full Name
abl interactor 2provided by HGNC
Primary source
HGNC:HGNC:24011
See related
Ensembl:ENSG00000138443 MIM:606442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB
Expression
Broad expression in brain (RPKM 35.9), thyroid (RPKM 13.9) and 21 other tissues See more
Orthologs

Genomic context

See ABI2 in Genome Data Viewer
Location:
2q33.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (203325013..203447728)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (204192597..204296892)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 20 subfamily A member 1 Neighboring gene RNA, 7SL, cytoplasmic 670, pseudogene Neighboring gene mitochondrial ribosomal protein L50 pseudogene 2 Neighboring gene tRNA-Glu (anticodon TTC) 9-1 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene zinc finger protein 207 pseudogene Neighboring gene NDUFA4, mitochondrial complex associated pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
NHGRI GWA Catalog
GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
contributes_to Rac GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH3 domain binding TAS
Traceable Author Statement
more info
PubMed 
cytoskeletal adaptor activity TAS
Traceable Author Statement
more info
PubMed 
kinase binding NAS
Non-traceable Author Statement
more info
PubMed 
proline-rich region binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
actin polymerization or depolymerization NAS
Non-traceable Author Statement
more info
PubMed 
cell migration TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
lens fiber cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCAR complex IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium tip IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
abl interactor 2
Names
abelson interactor 2
abl binding protein 3
abl-interacting protein 1 (SH3-containing protein)
abl-interactor protein 2b
arg protein tyrosine kinase-binding protein
arg-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282925.2NP_001269854.1  abl interactor 2 isoform a

    See identical proteins and their annotated locations for NP_001269854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC018891, AF260261, DB455742, R61525
    Consensus CDS
    CCDS63093.1
    UniProtKB/Swiss-Prot
    Q9NYB9
    UniProtKB/TrEMBL
    F8WAL6
    Related
    ENSP00000295851.4, ENST00000295851.10
    Conserved Domains (3) summary
    cd11972
    Location:452512
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:270397
    Atrophin-1; Atrophin-1 family
  2. NM_001282926.2NP_001269855.1  abl interactor 2 isoform b

    See identical proteins and their annotated locations for NP_001269855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC018891, AK299824, DB455742, R61525
    Consensus CDS
    CCDS63094.1
    UniProtKB/Swiss-Prot
    Q9NYB9
    UniProtKB/TrEMBL
    A0A0C4DG21
    Related
    ENSP00000391433.1, ENST00000424558.5
    Conserved Domains (3) summary
    cd11972
    Location:446506
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:264391
    Atrophin-1; Atrophin-1 family
  3. NM_001282927.1NP_001269856.1  abl interactor 2 isoform d

    See identical proteins and their annotated locations for NP_001269856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, differs in the presence and absence of exons in the 5' coding region, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC018891, DC376086, R61525, U23435
    UniProtKB/Swiss-Prot
    Q9NYB9
    Conserved Domains (2) summary
    cd11972
    Location:340400
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48118
    Abi_HHR; Abl-interactor HHR
  4. NM_001282932.1NP_001269861.1  abl interactor 2 isoform e

    See identical proteins and their annotated locations for NP_001269861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, differs in the presence and absence of exons in the 5' coding region, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC018891, AC080075, AK302853, DA693234, DB455742, R61525
    Consensus CDS
    CCDS74634.1
    UniProtKB/TrEMBL
    B7Z836
    Related
    ENSP00000261016.7, ENST00000261016.10
    Conserved Domains (2) summary
    cd11972
    Location:329389
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:37107
    Abi_HHR; Abl-interactor HHR
  5. NM_005759.6NP_005750.4  abl interactor 2 isoform c

    See identical proteins and their annotated locations for NP_005750.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, but includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC018891, BC001439, DB455742, R61525
    Consensus CDS
    CCDS2358.1
    UniProtKB/Swiss-Prot
    Q9NYB9
    Related
    ENSP00000261017.5, ENST00000261017.9
    Conserved Domains (2) summary
    cd11972
    Location:414474
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    203325013..203447728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452511.1XP_024308279.1  abl interactor 2 isoform X8

    Conserved Domains (3) summary
    cd11972
    Location:436496
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48124
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:225361
    Atrophin-1; Atrophin-1 family
  2. XM_006712185.1XP_006712248.1  abl interactor 2 isoform X40

    See identical proteins and their annotated locations for XP_006712248.1

    UniProtKB/Swiss-Prot
    Q9NYB9
    Conserved Domains (2) summary
    cd11972
    Location:340400
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48118
    Abi_HHR; Abl-interactor HHR
  3. XM_017003128.1XP_016858617.1  abl interactor 2 isoform X19

  4. XM_017003143.1XP_016858632.1  abl interactor 2 isoform X38

  5. XM_005246217.2XP_005246274.1  abl interactor 2 isoform X1

    See identical proteins and their annotated locations for XP_005246274.1

    Conserved Domains (3) summary
    cd11972
    Location:481541
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:270406
    Atrophin-1; Atrophin-1 family
  6. XM_006712174.3XP_006712237.1  abl interactor 2 isoform X2

    See identical proteins and their annotated locations for XP_006712237.1

    Conserved Domains (2) summary
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:481515
    SH3; Src Homology 3 domain superfamily
  7. XM_017003132.2XP_016858621.1  abl interactor 2 isoform X25

  8. XM_017003118.1XP_016858607.1  abl interactor 2 isoform X3

    Conserved Domains (3) summary
    cd11972
    Location:480540
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:269405
    Atrophin-1; Atrophin-1 family
  9. XM_017003120.2XP_016858609.1  abl interactor 2 isoform X5

  10. XM_017003121.1XP_016858610.1  abl interactor 2 isoform X7

  11. XM_006712179.2XP_006712242.1  abl interactor 2 isoform X9

    See identical proteins and their annotated locations for XP_006712242.1

    Conserved Domains (3) summary
    cd11972
    Location:432492
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:221357
    Atrophin-1; Atrophin-1 family
  12. XM_017003122.1XP_016858611.1  abl interactor 2 isoform X11

  13. XM_017003129.1XP_016858618.1  abl interactor 2 isoform X20

    Conserved Domains (3) summary
    cd11972
    Location:403463
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:221348
    Atrophin-1; Atrophin-1 family
  14. XM_011510472.2XP_011508774.1  abl interactor 2 isoform X10

    See identical proteins and their annotated locations for XP_011508774.1

    Conserved Domains (3) summary
    cd11972
    Location:431491
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:220356
    Atrophin-1; Atrophin-1 family
  15. XM_017003130.1XP_016858619.1  abl interactor 2 isoform X21

  16. XM_017003126.1XP_016858615.1  abl interactor 2 isoform X17

    Conserved Domains (2) summary
    cd11972
    Location:412472
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
  17. XM_005246226.2XP_005246283.1  abl interactor 2 isoform X28

    See identical proteins and their annotated locations for XP_005246283.1

    Conserved Domains (2) summary
    cd11972
    Location:385445
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
  18. XM_017003134.2XP_016858623.1  abl interactor 2 isoform X29

  19. XM_017003135.1XP_016858624.1  abl interactor 2 isoform X30

    Conserved Domains (2) summary
    cd11972
    Location:384444
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
  20. XM_017003141.1XP_016858630.1  abl interactor 2 isoform X36

  21. XM_017003145.1XP_016858634.1  abl interactor 2 isoform X43

  22. XM_006712177.3XP_006712240.1  abl interactor 2 isoform X8

    See identical proteins and their annotated locations for XP_006712240.1

    Conserved Domains (3) summary
    cd11972
    Location:436496
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48124
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:225361
    Atrophin-1; Atrophin-1 family
  23. XM_017003137.2XP_016858626.1  abl interactor 2 isoform X32

  24. XM_017003133.2XP_016858622.1  abl interactor 2 isoform X27

  25. XM_017003139.2XP_016858628.1  abl interactor 2 isoform X34

  26. XM_017003140.2XP_016858629.1  abl interactor 2 isoform X35

  27. XM_017003119.2XP_016858608.1  abl interactor 2 isoform X4

    Conserved Domains (3) summary
    cd11972
    Location:479539
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:270406
    Atrophin-1; Atrophin-1 family
  28. XM_006712180.3XP_006712243.1  abl interactor 2 isoform X14

    See identical proteins and their annotated locations for XP_006712243.1

    Conserved Domains (2) summary
    cd11972
    Location:420480
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
  29. XM_006712181.3XP_006712244.1  abl interactor 2 isoform X24

    See identical proteins and their annotated locations for XP_006712244.1

    Related
    ENSP00000396249.2, ENST00000422511.6
    Conserved Domains (2) summary
    cd11972
    Location:391451
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
  30. XM_006712182.3XP_006712245.1  abl interactor 2 isoform X26

    See identical proteins and their annotated locations for XP_006712245.1

    Conserved Domains (2) summary
    cd11972
    Location:390450
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
  31. XM_017003144.2XP_016858633.1  abl interactor 2 isoform X39

    Conserved Domains (2) summary
    cd11972
    Location:342402
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
  32. XM_017003138.2XP_016858627.1  abl interactor 2 isoform X33

    Conserved Domains (2) summary
    cd11972
    Location:370430
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93169
    Abi_HHR; Abl-interactor HHR
  33. XM_005246218.3XP_005246275.1  abl interactor 2 isoform X6

    See identical proteins and their annotated locations for XP_005246275.1

    Conserved Domains (3) summary
    cd11972
    Location:475535
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:264400
    Atrophin-1; Atrophin-1 family
  34. XM_017003125.2XP_016858614.1  abl interactor 2 isoform X16

    Conserved Domains (2) summary
    cd11972
    Location:413473
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
  35. XM_005246221.3XP_005246278.1  abl interactor 2 isoform X12

    See identical proteins and their annotated locations for XP_005246278.1

    Conserved Domains (3) summary
    cd11972
    Location:426486
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:215351
    Atrophin-1; Atrophin-1 family
  36. XM_005246225.3XP_005246282.1  abl interactor 2 isoform X22

    See identical proteins and their annotated locations for XP_005246282.1

    UniProtKB/TrEMBL
    E9PEZ7
    Related
    ENSP00000408898.1, ENST00000430418.5
    Conserved Domains (3) summary
    cd11972
    Location:397457
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
    cl26464
    Location:215342
    Atrophin-1; Atrophin-1 family
  37. XM_006712186.3XP_006712249.1  abl interactor 2 isoform X42

    See identical proteins and their annotated locations for XP_006712249.1

    Conserved Domains (2) summary
    cd11972
    Location:336396
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
  38. XM_017003123.2XP_016858612.1  abl interactor 2 isoform X13

  39. XM_017003131.2XP_016858620.1  abl interactor 2 isoform X23

  40. XM_017003142.2XP_016858631.1  abl interactor 2 isoform X37

  41. XM_017003127.1XP_016858616.1  abl interactor 2 isoform X18

    Conserved Domains (2) summary
    pfam07815
    Location:93163
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:413447
    SH3; Src Homology 3 domain superfamily
  42. XM_017003136.1XP_016858625.1  abl interactor 2 isoform X31

  43. XM_017003146.1XP_016858635.1  abl interactor 2 isoform X44

  44. XM_017003124.2XP_016858613.1  abl interactor 2 isoform X15

  45. XM_011510473.3XP_011508775.1  abl interactor 2 isoform X41

    See identical proteins and their annotated locations for XP_011508775.1

    Conserved Domains (1) summary
    cd11972
    Location:338398
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2

RNA

  1. XR_001738584.2 RNA Sequence

  2. XR_001738583.1 RNA Sequence

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