U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Inpp5f inositol polyphosphate-5-phosphatase F [ Mus musculus (house mouse) ]

Gene ID: 101490, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Official Symbol
Inpp5fprovided by MGI
Official Full Name
inositol polyphosphate-5-phosphatase Fprovided by MGI
Primary source
MGI:MGI:2141867
See related
Ensembl:ENSMUSG00000042105 AllianceGenome:MGI:2141867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SAC2; cI-27; hSAC2; mKIAA0966; 5830435P03Rik
Summary
Enables inositol monophosphate 4-phosphatase activity and phosphatidylinositol phosphate 4-phosphatase activity. Involved in several processes, including negative regulation of axon regeneration; phosphatidylinositol dephosphorylation; and positive regulation of receptor recycling. Acts upstream of or within cardiac muscle hypertrophy in response to stress; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol catabolic process. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; heart; retina; and spleen. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in CNS E18 (RPKM 34.5), whole brain E14.5 (RPKM 23.5) and 18 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Inpp5f in Genome Data Viewer
Location:
7 F3; 7 70.32 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128212905..128298161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128611181..128696436)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated athanogene 3 Neighboring gene STARR-seq mESC enhancer starr_20208 Neighboring gene STARR-positive B cell enhancer ABC_E1743 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3756 Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene minichromosome maintenance complex binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3757 Neighboring gene Sec23 interacting protein Neighboring gene STARR-seq mESC enhancer starr_20212

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression patterns of imprinted gene Inpp5f-v3 during mouse brain development. Yan C, et al. J Mol Histol, 2011 Apr. PMID 21424340
  2. A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island. Choi JD, et al. Mol Cell Biol, 2005 Jul. PMID 15964807, Free PMC Article
  3. Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1. Cao M, et al. Proc Natl Acad Sci U S A, 2020 Jun 2. PMID 32424101, Free PMC Article
  4. INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma. Zhou Q, et al. J Exp Clin Cancer Res, 2022 Jan 7. PMID 34996491, Free PMC Article
  5. Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. Hsu F, et al. J Cell Biol, 2015 Apr 13. PMID 25869669, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma.
    Title: INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma.
  2. Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.
    Title: Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.
  3. Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart.
    Title: Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart.
  4. This study reveals Inpp5f (Sac2) as a novel suppressor of CNS axon repair after spinal cord injury
    Title: Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.
  5. Sac2/INPP5F is a PI4P phosphatase that colocalizes with OCRL on endocytic membranes.
    Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.
  6. Inpp5f-v3 is specifically expressed in mouse brain, and may function in the development of mouse brain
    Title: Expression patterns of imprinted gene Inpp5f-v3 during mouse brain development.
  7. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness.
    Title: Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness.
  8. Study finds that the Inpp5f_v3 promoter acquires methylation at implantation, which is then lost specifically on the paternally derived allele during the latter stages development, resulting in imprinted activation on the demethylated allele.
    Title: Allele-specific demethylation at an imprinted mammalian promoter.
  9. A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island.
    Title: A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inositol monophosphate 4-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phosphate 4-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phosphate 4-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol phosphate 4-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in clathrin-coated endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositide phosphatase SAC2
Names
sac domain-containing inositol phosphatase 2
sac domain-containing phosphoinositide 4-phosphatase 2
sac domain-containing phosphoinositide 5-phosphatase 2
NP_001333446.1
NP_848756.2
XP_036008416.1
XP_036008417.1
XP_036008418.1
XP_036008419.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346517.1 → NP_001333446.1  phosphatidylinositide phosphatase SAC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122767, AK030870, BU708345, BU709063
    Consensus CDS
    CCDS85430.1
    UniProtKB/Swiss-Prot
    Q8CDA1
    Related
    ENSMUSP00000113700.2, ENSMUST00000118605.2

  2. NM_178641.5 → NP_848756.2  phosphatidylinositide phosphatase SAC2 isoform 1

    See identical proteins and their annotated locations for NP_848756.2

    Status: VALIDATED

    Source sequence(s)
    AC122767
    Consensus CDS
    CCDS21899.1
    UniProtKB/Swiss-Prot
    Q3UCS0, Q6NX83, Q6ZQ16, Q8C8G7, Q8CBW2, Q8CDA1
    UniProtKB/TrEMBL
    B2RQ14
    Related
    ENSMUSP00000045910.7, ENSMUST00000043138.13
    Conserved Domains (2) summary
    pfam02383
    Location:50 → 415
    Syja_N; SacI homology domain
    pfam12456
    Location:595 → 697
    hSac2; Inositol phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    128212905..128298161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152526.1 → XP_036008419.1  phosphatidylinositide phosphatase SAC2 isoform X4

    Conserved Domains (1) summary
    pfam02383
    Location:50 → 223
    Syja_N; SacI homology domain

  2. XM_036152523.1 → XP_036008416.1  phosphatidylinositide phosphatase SAC2 isoform X1

    Conserved Domains (2) summary
    COG5329
    Location:79 → 472
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam12456
    Location:500 → 601
    hSac2; Inositol phosphatase

  3. XM_036152524.1 → XP_036008417.1  phosphatidylinositide phosphatase SAC2 isoform X2

    Conserved Domains (2) summary
    COG5329
    Location:7 → 400
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam12456
    Location:428 → 529
    hSac2; Inositol phosphatase

  4. XM_036152525.1 → XP_036008418.1  phosphatidylinositide phosphatase SAC2 isoform X3

    Related
    ENSMUSP00000146197.2, ENSMUST00000151237.5

RNA

  1. XR_004933992.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDA1.1 GenPept UniProtKB/Swiss-Prot:Q8CDA1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous