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Inpp5f inositol polyphosphate-5-phosphatase F [ Mus musculus (house mouse) ]

Gene ID: 101490, updated on 7-May-2024

Summary

Official Symbol
Inpp5fprovided by MGI
Official Full Name
inositol polyphosphate-5-phosphatase Fprovided by MGI
Primary source
MGI:MGI:2141867
See related
Ensembl:ENSMUSG00000042105 AllianceGenome:MGI:2141867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SAC2; cI-27; hSAC2; mKIAA0966; 5830435P03Rik
Summary
Enables inositol monophosphate 4-phosphatase activity and phosphatidylinositol phosphate 4-phosphatase activity. Involved in several processes, including negative regulation of axon regeneration; phosphatidylinositol dephosphorylation; and positive regulation of receptor recycling. Acts upstream of or within cardiac muscle hypertrophy in response to stress; phosphatidylinositol catabolic process; and phosphatidylinositol-mediated signaling. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; heart; retina; and spleen. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 34.5), whole brain E14.5 (RPKM 23.5) and 18 other tissues See more
Orthologs
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Genomic context

See Inpp5f in Genome Data Viewer
Location:
7 F3; 7 70.32 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128212905..128298161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128611181..128696436)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated athanogene 3 Neighboring gene STARR-seq mESC enhancer starr_20208 Neighboring gene STARR-positive B cell enhancer ABC_E1743 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3756 Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene minichromosome maintenance complex binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3757 Neighboring gene Sec23 interacting protein Neighboring gene STARR-seq mESC enhancer starr_20212

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphatidylinositol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in clathrin-coated endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in clathrin-coated endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylinositide phosphatase SAC2
Names
sac domain-containing inositol phosphatase 2
sac domain-containing phosphoinositide 4-phosphatase 2
sac domain-containing phosphoinositide 5-phosphatase 2
NP_001333446.1
NP_848756.2
XP_036008416.1
XP_036008417.1
XP_036008418.1
XP_036008419.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346517.1NP_001333446.1  phosphatidylinositide phosphatase SAC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122767, AK030870, BU708345, BU709063
    Consensus CDS
    CCDS85430.1
    UniProtKB/Swiss-Prot
    Q8CDA1
    Related
    ENSMUSP00000113700.2, ENSMUST00000118605.2
  2. NM_178641.5NP_848756.2  phosphatidylinositide phosphatase SAC2 isoform 1

    See identical proteins and their annotated locations for NP_848756.2

    Status: VALIDATED

    Source sequence(s)
    AC122767
    Consensus CDS
    CCDS21899.1
    UniProtKB/Swiss-Prot
    Q3UCS0, Q6NX83, Q6ZQ16, Q8C8G7, Q8CBW2, Q8CDA1
    UniProtKB/TrEMBL
    B2RQ14
    Related
    ENSMUSP00000045910.7, ENSMUST00000043138.13
    Conserved Domains (2) summary
    pfam02383
    Location:50415
    Syja_N; SacI homology domain
    pfam12456
    Location:595697
    hSac2; Inositol phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    128212905..128298161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152526.1XP_036008419.1  phosphatidylinositide phosphatase SAC2 isoform X4

    Conserved Domains (1) summary
    pfam02383
    Location:50223
    Syja_N; SacI homology domain
  2. XM_036152523.1XP_036008416.1  phosphatidylinositide phosphatase SAC2 isoform X1

    Conserved Domains (2) summary
    COG5329
    Location:79472
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam12456
    Location:500601
    hSac2; Inositol phosphatase
  3. XM_036152524.1XP_036008417.1  phosphatidylinositide phosphatase SAC2 isoform X2

    Conserved Domains (2) summary
    COG5329
    Location:7400
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam12456
    Location:428529
    hSac2; Inositol phosphatase
  4. XM_036152525.1XP_036008418.1  phosphatidylinositide phosphatase SAC2 isoform X3

    Related
    ENSMUSP00000146197.2, ENSMUST00000151237.5

RNA

  1. XR_004933992.1 RNA Sequence