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ADGRG2 adhesion G protein-coupled receptor G2 [ Homo sapiens (human) ]

Gene ID: 10149, updated on 25-May-2017
Official Symbol
ADGRG2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G2provided by HGNC
Primary source
HGNC:HGNC:4516
See related
Ensembl:ENSG00000173698 MIM:300572; Vega:OTTHUMG00000021223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HE6; EDDM6; GPR64; CBAVDX; TM7LN2
Summary
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Orthologs
Location:
Xp22.13
Exon count:
32
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (18989307..19122956, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (19007425..19140755, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene HAUS augmin like complex subunit 1 pseudogene 2 Neighboring gene PHKA2 antisense RNA 1 Neighboring gene phosphorylase kinase regulatory subunit alpha 2 Neighboring gene uncharacterized LOC101928415 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene pyruvate dehydrogenase alpha 1 Neighboring gene eukaryotic translation initiation factor 5 pseudogene 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

Markers

Homology

Clone Names

  • FLJ00282, MGC104454, MGC138738, MGC138739

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
adhesion G-protein coupled receptor G2
Names
G protein-coupled receptor 64
G protein-coupled receptor, epididymis-specific (seven transmembrane family)
epididymal protein 6
human epididymis-specific protein 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021304.1 RefSeqGene

    Range
    5001..138331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001079858.2NP_001073327.1  adhesion G-protein coupled receptor G2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001073327.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF538954, BC063315, X81892
    Consensus CDS
    CCDS43923.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    Related
    ENSP00000369198.3, OTTHUMP00000023010, ENST00000379869.7, OTTHUMT00000055970
    Conserved Domains (2) summary
    pfam01825
    Location:569612
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:625875
    7tm_4; Olfactory receptor
  2. NM_001079859.2NP_001073328.1  adhesion G-protein coupled receptor G2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC063315, BC099901, X81892
    Consensus CDS
    CCDS43922.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    UniProtKB/TrEMBL
    Q499H0
    Related
    ENSP00000349015.4, OTTHUMP00000215232, ENST00000356606.8, OTTHUMT00000355219
    Conserved Domains (2) summary
    pfam01825
    Location:555598
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:611861
    7tm_4; Olfactory receptor
  3. NM_001079860.2NP_001073329.1  adhesion G-protein coupled receptor G2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF539456, BC063315, X81892
    Consensus CDS
    CCDS43921.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    Related
    ENSP00000353421.4, OTTHUMP00000023011, ENST00000360279.8, OTTHUMT00000055972
    Conserved Domains (2) summary
    pfam01825
    Location:547590
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:603853
    7tm_4; Olfactory receptor
  4. NM_001184833.1NP_001171762.1  adhesion G-protein coupled receptor G2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF538954, AY143366, BC063315, X81892
    Consensus CDS
    CCDS55378.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    Related
    ENSP00000369207.3, ENST00000379878.7
    Conserved Domains (2) summary
    pfam01825
    Location:553596
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:609859
    7tm_4; Olfactory receptor
  5. NM_001184834.1NP_001171763.1  adhesion G-protein coupled receptor G2 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF538954, AY148343, BC063315
    Consensus CDS
    CCDS55379.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    Related
    ENSP00000369202.2, OTTHUMP00000023008, ENST00000379873.6, OTTHUMT00000055968
    Conserved Domains (2) summary
    pfam01825
    Location:569612
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:625875
    7tm_4; Olfactory receptor
  6. NM_001184835.1NP_001171764.1  adhesion G-protein coupled receptor G2 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AY143364, BC063315, X81892
    UniProtKB/Swiss-Prot
    Q8IZP9
    Conserved Domains (2) summary
    pfam01825
    Location:531574
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:587837
    7tm_4; Olfactory receptor
  7. NM_001184836.1NP_001171765.1  adhesion G-protein coupled receptor G2 isoform 8 precursor

    See identical proteins and their annotated locations for NP_001171765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF538954, AY143367, BC063315, X81892
    Consensus CDS
    CCDS55376.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    Related
    ENSP00000369205.1, ENST00000379876.5
    Conserved Domains (2) summary
    pfam01825
    Location:545588
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:601851
    7tm_4; Olfactory receptor
  8. NM_001184837.1NP_001171766.1  adhesion G-protein coupled receptor G2 isoform 9 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF539455, BC063315, X81892
    Consensus CDS
    CCDS55377.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    Related
    ENSP00000350152.3, OTTHUMP00000023009, ENST00000357544.7, OTTHUMT00000055969
    Conserved Domains (2) summary
    pfam01825
    Location:539582
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:595845
    7tm_4; Olfactory receptor
  9. NM_005756.3NP_005747.2  adhesion G-protein coupled receptor G2 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK291012, BC063315, X81892
    Consensus CDS
    CCDS14191.1
    UniProtKB/Swiss-Prot
    Q8IZP9
    UniProtKB/TrEMBL
    A8K4P7
    Related
    ENSP00000350680.3, OTTHUMP00000023012, ENST00000357991.7, OTTHUMT00000055973
    Conserved Domains (2) summary
    pfam01825
    Location:566609
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:622872
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

    Range
    18989307..19122956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724455.3XP_006724518.1  adhesion G-protein coupled receptor G2 isoform X1

    See identical proteins and their annotated locations for XP_006724518.1

    UniProtKB/Swiss-Prot
    Q8IZP9
    Conserved Domains (2) summary
    pfam01825
    Location:569612
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:625875
    7tm_4; Olfactory receptor
  2. XM_011545434.1XP_011543736.1  adhesion G-protein coupled receptor G2 isoform X1

    See identical proteins and their annotated locations for XP_011543736.1

    UniProtKB/Swiss-Prot
    Q8IZP9
    Conserved Domains (2) summary
    pfam01825
    Location:569612
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:625875
    7tm_4; Olfactory receptor
  3. XM_011545435.2XP_011543737.1  adhesion G-protein coupled receptor G2 isoform X1

    See identical proteins and their annotated locations for XP_011543737.1

    UniProtKB/Swiss-Prot
    Q8IZP9
    Conserved Domains (2) summary
    pfam01825
    Location:569612
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:625875
    7tm_4; Olfactory receptor

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    19038499..19171850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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