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EBI3 Epstein-Barr virus induced 3 [ Homo sapiens (human) ]

Gene ID: 10148, updated on 11-Sep-2019

Summary

Official Symbol
EBI3provided by HGNC
Official Full Name
Epstein-Barr virus induced 3provided by HGNC
Primary source
HGNC:HGNC:3129
See related
Ensembl:ENSG00000105246 MIM:605816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL27B; IL35B; IL-27B
Summary
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Expression
Biased expression in placenta (RPKM 82.3), spleen (RPKM 9.3) and 2 other tissues See more
Orthologs

Genomic context

See EBI3 in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4229196..4237539)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4229540..4237525)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sirtuin 6 Neighboring gene ankyrin repeat domain 24 Neighboring gene YJU2 splicing factor homolog Neighboring gene Src homology 2 domain containing transforming protein D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of Epstein-Barr virus induced 3 (EBI3, IL-27B) in human primary T cells PubMed
Vpr vpr HIV-1 Vpr downregulates the expression of EBI3 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • IL-6-type cytokine receptor ligand interactions, organism-specific biosystem (from REACTOME)
    IL-6-type cytokine receptor ligand interactions, organism-specific biosystemThe members involved in (interleukin)-6-type cytokine signalling are the IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CTF1)...
  • IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL27-mediated signaling events, organism-specific biosystem
    IL27-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-6 family signaling, organism-specific biosystem (from REACTOME)
    Interleukin-6 family signaling, organism-specific biosystemThe interleukin (IL)-6 family of cytokines is defined by the shared use of the common signal transducing receptor gp130 beta-subunit. This family includes structurally and functionally related IL-6, ...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ciliary neurotrophic factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-27 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
CNTFR-CLCF1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary neurotrophic factor receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-27 subunit beta
Names
EBV-induced gene 3 protein
Epstein-Barr virus induced gene 3
IL-27 subunit beta
IL27 subunit
IL35 subunit
cytokine receptor
epstein-Barr virus-induced gene 3 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005755.3NP_005746.2  interleukin-27 subunit beta precursor

    See identical proteins and their annotated locations for NP_005746.2

    Status: REVIEWED

    Source sequence(s)
    AC005578
    Consensus CDS
    CCDS12123.1
    UniProtKB/Swiss-Prot
    Q14213
    Related
    ENSP00000221847.4, ENST00000221847.6
    Conserved Domains (2) summary
    smart00060
    Location:47115
    FN3; Fibronectin type 3 domain
    cd00063
    Location:129224
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4229196..4237539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527619.2XP_011525921.1  interleukin-27 subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011525921.1

    UniProtKB/Swiss-Prot
    Q14213
    Conserved Domains (2) summary
    smart00060
    Location:47115
    FN3; Fibronectin type 3 domain
    cd00063
    Location:129224
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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