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SUGP2 SURP and G-patch domain containing 2 [ Homo sapiens (human) ]

Gene ID: 10147, updated on 8-Jul-2018
Official Symbol
SUGP2provided by HGNC
Official Full Name
SURP and G-patch domain containing 2provided by HGNC
Primary source
HGNC:HGNC:18641
See related
Ensembl:ENSG00000064607 MIM:607993; Vega:OTTHUMG00000182997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFRS14; SRFS14
Summary
This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Expression
Broad expression in testis (RPKM 45.5), brain (RPKM 19.3) and 24 other tissues See more
Orthologs
See SUGP2 in Genome Data Viewer
Location:
19p13.11
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (18990887..19034052, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19101697..19144861, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985268 Neighboring gene RNA, 7SL, cytoplasmic 70, pseudogene Neighboring gene armadillo repeat containing 6 Neighboring gene solute carrier family 25 member 42 Neighboring gene transmembrane protein 161A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ21855, DKFZp686M2322, DKFZp779L2418

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
SURP and G-patch domain-containing protein 2
Names
arginine/serine-rich-splicing factor 14
splicing factor, arginine/serine-rich 14

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017392.4NP_001017392.2  SURP and G-patch domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001017392.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC004447, AL832488, BG166266, BX647813, DC335817
    Consensus CDS
    CCDS12392.1
    UniProtKB/Swiss-Prot
    Q8IX01
    Related
    ENSP00000389380.1, OTTHUMP00000270650, ENST00000452918.6, OTTHUMT00000464625
    Conserved Domains (3) summary
    smart00443
    Location:10091054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589639
    Surp; Surp module
  2. NM_001321697.1NP_001308626.1  SURP and G-patch domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004447, BG166266, DA217559, DA770920
    Consensus CDS
    CCDS12392.1
    UniProtKB/Swiss-Prot
    Q8IX01
    Related
    ENSP00000470915.1, OTTHUMP00000270647, ENST00000594773.5, OTTHUMT00000464619
    Conserved Domains (3) summary
    smart00443
    Location:10091054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589639
    Surp; Surp module
  3. NM_001321698.1NP_001308627.1  SURP and G-patch domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004447, BG166266
    Consensus CDS
    CCDS82322.1
    UniProtKB/TrEMBL
    M0R2Z9
    Related
    OTTHUMP00000270653, OTTHUMT00000464628
    Conserved Domains (3) summary
    smart00443
    Location:10231068
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:799852
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:603653
    Surp; Surp module
  4. NM_001321699.1NP_001308628.1  SURP and G-patch domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004447, BG166266, DC402794
    Consensus CDS
    CCDS82322.1
    UniProtKB/TrEMBL
    M0R2Z9
    Conserved Domains (3) summary
    smart00443
    Location:10231068
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:799852
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:603653
    Surp; Surp module
  5. NM_001352071.1NP_001339000.1  SURP and G-patch domain-containing protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC004447, AL832488, BG166266, BX647813, DA217559, DA240141
    Consensus CDS
    CCDS12392.1
    Related
    ENSP00000472286.1, ENST00000601879.5
    Conserved Domains (3) summary
    smart00443
    Location:10091054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589639
    Surp; Surp module
  6. NM_014884.4NP_055699.2  SURP and G-patch domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055699.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AF518874, AK291275, BG166266, DC335817
    Consensus CDS
    CCDS12392.1
    UniProtKB/Swiss-Prot
    Q8IX01
    UniProtKB/TrEMBL
    A8K5G0
    Related
    ENSP00000337926.5, OTTHUMP00000270649, ENST00000337018.10, OTTHUMT00000464623
    Conserved Domains (3) summary
    smart00443
    Location:10091054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589639
    Surp; Surp module

RNA

  1. NR_147913.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004447, AF518874, AK291275, BE166620, BG166266, CA422995, CB160925, DC335817
  2. NR_147914.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF518874, AK291275, BG166266, BU730975, DC335817
  3. NR_147915.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA505711, AC004447, AF518874, AK291275, BE622050, BG166266, CA422995, DA217559, DA240141

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    18990887..19034052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451308.1XP_024307076.1  SURP and G-patch domain-containing protein 2 isoform X2

    Related
    ENSP00000472914.1, ENST00000600377.1
    Conserved Domains (3) summary
    smart00443
    Location:10231068
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:799852
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:603653
    Surp; Surp module
  2. XM_024451307.1XP_024307075.1  SURP and G-patch domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    smart00648
    Location:799852
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam01585
    Location:10261057
    G-patch; G-patch domain
    cl02715
    Location:603653
    Surp; Surp module

RNA

  1. XR_001753577.2 RNA Sequence

  2. XR_002958239.1 RNA Sequence

  3. XR_430124.4 RNA Sequence

  4. XR_001753576.2 RNA Sequence

  5. XR_430122.4 RNA Sequence

  6. XR_002958236.1 RNA Sequence

  7. XR_001753575.2 RNA Sequence

  8. XR_430120.4 RNA Sequence

  9. XR_001753574.2 RNA Sequence

  10. XR_002958235.1 RNA Sequence

  11. XR_001753573.2 RNA Sequence

  12. XR_936140.3 RNA Sequence

  13. XR_936141.3 RNA Sequence

  14. XR_936139.3 RNA Sequence

  15. XR_936138.3 RNA Sequence

  16. XR_936137.3 RNA Sequence

  17. XR_936144.3 RNA Sequence

  18. XR_936143.3 RNA Sequence

  19. XR_001753580.2 RNA Sequence

  20. XR_936142.2 RNA Sequence

  21. XR_002958237.1 RNA Sequence

  22. XR_002958238.1 RNA Sequence

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