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Adamts9 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 [ Mus musculus (house mouse) ]

Gene ID: 101401, updated on 26-Sep-2022

Summary

Official Symbol
Adamts9provided by MGI
Official Full Name
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9provided by MGI
Primary source
MGI:MGI:1916320
See related
Ensembl:ENSMUSG00000030022 AllianceGenome:MGI:1916320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UND3; UND4; Gsfund3; Mhdaund3; Mhdaund4; 1810011L16Rik; 8430403M15Rik; E030027K14Rik
Summary
Enables endopeptidase activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell migration; and negative regulation of sprouting angiogenesis. Acts upstream of or within positive regulation of melanocyte differentiation; proteolysis; and response to bacterium. Located in cell surface and extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; eye; and genitourinary system. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 5.9), subcutaneous fat pad adult (RPKM 3.5) and 22 other tissues See more
Orthologs
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Genomic context

See Adamts9 in Genome Data Viewer
Location:
6; 6 D1
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (92749680..92921431, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (92772699..92944450, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene prickle planar cell polarity protein 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RNA binding motif protein 17 pseudogene Neighboring gene RIKEN cDNA A730049H05 gene Neighboring gene predicted gene, 52913 Neighboring gene predicted gene 15737 Neighboring gene RIKEN cDNA 9530026P05 gene Neighboring gene VISTA enhancer mm1713 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (9)  1 citation
  • Chemically induced (ENU) (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 9
Names
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175314.4NP_780523.3  A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC110378, AC166101
    Consensus CDS
    CCDS51855.2
    UniProtKB/TrEMBL
    E9PUN6
    Related
    ENSMUSP00000109065.2, ENSMUST00000113438.8
    Conserved Domains (5) summary
    smart00209
    Location:591642
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293496
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:753871
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:49207
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:17341930
    GON; GON domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    92749680..92921431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165715.1XP_036021608.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X5

    Conserved Domains (7) summary
    smart00209
    Location:591642
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293496
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:753871
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:49207
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:16391835
    GON; GON domain
    pfam17771
    Location:511578
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:12871340
    TSP1_ADAMTS; Thrombospondin type 1 domain
  2. XM_036165714.1XP_036021607.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2

    Conserved Domains (7) summary
    smart00209
    Location:591642
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293496
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:753871
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:49207
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:16791875
    GON; GON domain
    pfam17771
    Location:511578
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:10561110
    TSP1_ADAMTS; Thrombospondin type 1 domain
  3. XM_036165713.1XP_036021606.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X1

    Conserved Domains (7) summary
    smart00209
    Location:591642
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293496
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:753871
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:49207
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08685
    Location:16941890
    GON; GON domain
    pfam17771
    Location:511578
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:13421395
    TSP1_ADAMTS; Thrombospondin type 1 domain
  4. XM_006505263.4XP_006505326.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X6

    Conserved Domains (6) summary
    smart00209
    Location:591642
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293496
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:49207
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:753871
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08685
    Location:16201816
    GON; GON domain
    pfam17771
    Location:511578
    ADAM_CR_2; ADAM cysteine-rich domain
  5. XM_006505261.4XP_006505324.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X3

    Conserved Domains (6) summary
    smart00209
    Location:591642
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293496
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:49207
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:753871
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08685
    Location:16781874
    GON; GON domain
    pfam17771
    Location:511578
    ADAM_CR_2; ADAM cysteine-rich domain
  6. XM_006505262.4XP_006505325.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X4

    Conserved Domains (6) summary
    smart00209
    Location:591642
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293496
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:49207
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:753871
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08685
    Location:16761872
    GON; GON domain
    pfam17771
    Location:511578
    ADAM_CR_2; ADAM cysteine-rich domain