Format

Send to:

Choose Destination

RBM12 RNA binding motif protein 12 [ Homo sapiens (human) ]

Gene ID: 10137, updated on 5-Aug-2018

Summary

Official Symbol
RBM12provided by HGNC
Official Full Name
RNA binding motif protein 12provided by HGNC
Primary source
HGNC:HGNC:9898
See related
Ensembl:ENSG00000244462 MIM:607179; Vega:OTTHUMG00000032350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SWAN; SCZD19; HRIHFB2091
Summary
This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in lymph node (RPKM 14.4), ovary (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See RBM12 in Genome Data Viewer
Location:
20q11.22
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (35648925..35664956, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34236847..34252878, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene copine 1 Neighboring gene RNA, 7SK small nuclear pseudogene 271 Neighboring gene RNA, U6 small nuclear 759, pseudogene Neighboring gene NFS1, cysteine desulfurase Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
RNA-binding protein 12
Names
SH3/WW domain anchor protein in the nucleus

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198838.1NP_001185767.1  RNA-binding protein 12

    See identical proteins and their annotated locations for NP_001185767.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AA825305, AL109827, DA319853, DB060608
    Consensus CDS
    CCDS13261.1
    UniProtKB/Swiss-Prot
    Q9NTZ6
    Conserved Domains (6) summary
    cd12512
    Location:421521
    RRM3_RBM12; RNA recognition motif 3 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12745
    Location:192
    RRM1_RBM12; RNA recognition motif 1 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12747
    Location:303377
    RRM2_RBM12; RNA recognition motif 2 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12749
    Location:545632
    RRM4_RBM12; RNA recognition motif 4 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12751
    Location:855929
    RRM5_RBM12; RNA recognition motif 5 in RNA-binding protein 12 (RBM12) and similar proteins
    pfam05642
    Location:633764
    Sporozoite_P67; Sporozoite P67 surface antigen
  2. NM_001198840.1NP_001185769.1  RNA-binding protein 12

    See identical proteins and their annotated locations for NP_001185769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AA825305, AB018308, AL109827, DB060608
    Consensus CDS
    CCDS13261.1
    UniProtKB/Swiss-Prot
    Q9NTZ6
    Related
    ENSP00000352668.1, OTTHUMP00000062718, ENST00000359646.1, OTTHUMT00000127165
    Conserved Domains (6) summary
    cd12512
    Location:421521
    RRM3_RBM12; RNA recognition motif 3 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12745
    Location:192
    RRM1_RBM12; RNA recognition motif 1 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12747
    Location:303377
    RRM2_RBM12; RNA recognition motif 2 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12749
    Location:545632
    RRM4_RBM12; RNA recognition motif 4 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12751
    Location:855929
    RRM5_RBM12; RNA recognition motif 5 in RNA-binding protein 12 (RBM12) and similar proteins
    pfam05642
    Location:633764
    Sporozoite_P67; Sporozoite P67 surface antigen
  3. NM_006047.5NP_006038.2  RNA-binding protein 12

    See identical proteins and their annotated locations for NP_006038.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. All variants encode the same protein.
    Source sequence(s)
    AA825305, AF345332, AL109827, DB060608
    Consensus CDS
    CCDS13261.1
    UniProtKB/Swiss-Prot
    Q9NTZ6
    Related
    ENSP00000363228.3, OTTHUMP00000030766, ENST00000374114.7, OTTHUMT00000078894
    Conserved Domains (6) summary
    cd12512
    Location:421521
    RRM3_RBM12; RNA recognition motif 3 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12745
    Location:192
    RRM1_RBM12; RNA recognition motif 1 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12747
    Location:303377
    RRM2_RBM12; RNA recognition motif 2 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12749
    Location:545632
    RRM4_RBM12; RNA recognition motif 4 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12751
    Location:855929
    RRM5_RBM12; RNA recognition motif 5 in RNA-binding protein 12 (RBM12) and similar proteins
    pfam05642
    Location:633764
    Sporozoite_P67; Sporozoite P67 surface antigen
  4. NM_152838.3NP_690051.1  RNA-binding protein 12

    See identical proteins and their annotated locations for NP_690051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AA825305, AF393214, AL109827, DB060608
    Consensus CDS
    CCDS13261.1
    UniProtKB/Swiss-Prot
    Q9NTZ6
    Related
    ENSP00000363217.3, OTTHUMP00000062717, ENST00000374104.7, OTTHUMT00000127164
    Conserved Domains (6) summary
    cd12512
    Location:421521
    RRM3_RBM12; RNA recognition motif 3 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12745
    Location:192
    RRM1_RBM12; RNA recognition motif 1 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12747
    Location:303377
    RRM2_RBM12; RNA recognition motif 2 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12749
    Location:545632
    RRM4_RBM12; RNA recognition motif 4 in RNA-binding protein 12 (RBM12) and similar proteins
    cd12751
    Location:855929
    RRM5_RBM12; RNA recognition motif 5 in RNA-binding protein 12 (RBM12) and similar proteins
    pfam05642
    Location:633764
    Sporozoite_P67; Sporozoite P67 surface antigen

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    35648925..35664956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center