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NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens (human) ]

Gene ID: 10135, updated on 12-May-2019

Summary

Official Symbol
NAMPTprovided by HGNC
Official Full Name
nicotinamide phosphoribosyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:30092
See related
Ensembl:ENSG00000105835 MIM:608764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
Summary
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Expression
Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues See more
Orthologs

Genomic context

See NAMPT in Genome Data Viewer
Location:
7q22.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (106248285..106285192, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105888731..105926373, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 1 Neighboring gene RNA, U6 small nuclear 392, pseudogene Neighboring gene La ribonucleoprotein domain family member 1B pseudogene 2 Neighboring gene uncharacterized CTB-30L5.1 Neighboring gene uncharacterized LOC105375440

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
tat HIV-1 Tat-induced inhibition of NAMPT protein expression and depletion of NAD(+) levels in TZM-bl cells are reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
tat HIV-1 Tat upregulates miR-182 in TZM-bl cells. MiR-182 significantly inhibits NAMPT protein expression by acting on the 3'-UTR of the NAMPT mRNA PubMed
tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • NAD metabolism, sirtuins and aging, organism-specific biosystem (from WikiPathways)
    NAD metabolism, sirtuins and aging, organism-specific biosystemA model for DNA damage, inflammation, NAD+, and aging. Two key events, the activation of PARP by DNA damage and the decreased NAMPT expression associated with inflammation, lead to decreased SIRT1 an...
  • NAD salvage, organism-specific biosystem (from BIOCYC)
    NAD salvage, organism-specific biosystemGeneral Background Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative, nicotinamide adenine dinucleotidephosphate (NADP) are two of the most important coenzymes in redox react...
  • NAD+ biosynthetic pathways, organism-specific biosystem (from WikiPathways)
    NAD+ biosynthetic pathways, organism-specific biosystemNAD+ biosynthetic pathways. NAD+ levels are maintained by three independent pathways. First, the Preiss-Handler pathway uses dietary nicotinic acid and the enzyme nicotinic acid phosphoribosyltransfe...
  • NAD+ metabolism, organism-specific biosystem (from WikiPathways)
    NAD+ metabolism, organism-specific biosystemNAD+ metabolism in different cellular compartments. The different precursors to intracellular NAD metabolism - tryptophan, nicotinic acid (NA), nicotinamide, NR, and NMN - are shown, along with their...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Nicotinamide salvaging, organism-specific biosystem (from REACTOME)
    Nicotinamide salvaging, organism-specific biosystemNicotinamide (NAM) levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosp...
  • Nicotinate and nicotinamide metabolism, organism-specific biosystem (from KEGG)
    Nicotinate and nicotinamide metabolism, organism-specific biosystem
    Nicotinate and nicotinamide metabolism
  • Nicotinate and nicotinamide metabolism, conserved biosystem (from KEGG)
    Nicotinate and nicotinamide metabolism, conserved biosystem
    Nicotinate and nicotinamide metabolism
  • Nicotinate metabolism, organism-specific biosystem (from REACTOME)
    Nicotinate metabolism, organism-specific biosystemNicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are intercha...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117256, DKFZp666B131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nicotinamide phosphoribosyltransferase activity TAS
Traceable Author Statement
more info
 
nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
NOT adipose tissue development IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxygen-glucose deprivation IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm TAS
Traceable Author Statement
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
NOT insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lung blood pressure IEA
Inferred from Electronic Annotation
more info
 
response to D-galactose IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nicotinamide phosphoribosyltransferase
Names
NAmPRTase
pre-B cell-enhancing factor
pre-B-cell colony-enhancing factor 1
NP_005737.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005746.3NP_005737.1  nicotinamide phosphoribosyltransferase precursor

    See identical proteins and their annotated locations for NP_005737.1

    Status: REVIEWED

    Source sequence(s)
    AC007032, AI299587, BC106046, U02020
    Consensus CDS
    CCDS5737.1
    UniProtKB/Swiss-Prot
    P43490
    UniProtKB/TrEMBL
    A0A024R718
    Related
    ENSP00000222553.3, ENST00000222553.8
    Conserved Domains (1) summary
    cd01569
    Location:12428
    PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    106248285..106285192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182790.1: Suppressed sequence

    Description
    NM_182790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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