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NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens (human) ]

Gene ID: 10135, updated on 19-Jun-2022

Summary

Official Symbol
NAMPTprovided by HGNC
Official Full Name
nicotinamide phosphoribosyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:30092
See related
Ensembl:ENSG00000105835 MIM:608764; AllianceGenome:HGNC:30092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
Summary
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Expression
Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues See more
Orthologs
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Genomic context

See NAMPT in Genome Data Viewer
Location:
7q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (106248298..106285888, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (107563712..107600408, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105888744..105925429, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901719 Neighboring gene RNA, U6 small nuclear 392, pseudogene Neighboring gene LARP1B pseudogene 2 Neighboring gene uncharacterized CTB-30L5.1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
tat HIV-1 Tat-induced inhibition of NAMPT protein expression and depletion of NAD(+) levels in TZM-bl cells are reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
tat HIV-1 Tat upregulates miR-182 in TZM-bl cells. MiR-182 significantly inhibits NAMPT protein expression by acting on the 3'-UTR of the NAMPT mRNA PubMed
tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117256, DKFZp666B131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nicotinamide phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nicotinamide phosphoribosyltransferase activity TAS
Traceable Author Statement
more info
 
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nicotinamide phosphoribosyltransferase
Names
NAmPRTase
pre-B cell-enhancing factor
pre-B-cell colony-enhancing factor 1
NP_005737.1
XP_047275655.1
XP_047275656.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005746.3NP_005737.1  nicotinamide phosphoribosyltransferase precursor

    See identical proteins and their annotated locations for NP_005737.1

    Status: REVIEWED

    Source sequence(s)
    AC007032, AI299587, BC106046, U02020
    Consensus CDS
    CCDS5737.1
    UniProtKB/Swiss-Prot
    P43490
    UniProtKB/TrEMBL
    A0A024R718
    Related
    ENSP00000222553.3, ENST00000222553.8
    Conserved Domains (1) summary
    cd01569
    Location:12428
    PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    106248298..106285888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419699.1XP_047275655.1  nicotinamide phosphoribosyltransferase isoform X1

    Related
    ENSP00000390591.2, ENST00000424768.2
  2. XM_047419700.1XP_047275656.1  nicotinamide phosphoribosyltransferase isoform X2

    Related
    ENSP00000505390.1, ENST00000681391.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    107563712..107600408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182790.1: Suppressed sequence

    Description
    NM_182790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.