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NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens (human) ]

Gene ID: 10135, updated on 9-Jan-2022


Official Symbol
NAMPTprovided by HGNC
Official Full Name
nicotinamide phosphoribosyltransferaseprovided by HGNC
Primary source
See related
Ensembl:ENSG00000105835 MIM:608764
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues See more
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Genomic context

See NAMPT in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (106248298..106284983, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105888744..105925429, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 1 Neighboring gene RNA, U6 small nuclear 392, pseudogene Neighboring gene LARP1B pseudogene 2 Neighboring gene uncharacterized CTB-30L5.1 Neighboring gene uncharacterized LOC105375440

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
tat HIV-1 Tat-induced inhibition of NAMPT protein expression and depletion of NAD(+) levels in TZM-bl cells are reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
tat HIV-1 Tat upregulates miR-182 in TZM-bl cells. MiR-182 significantly inhibits NAMPT protein expression by acting on the 3'-UTR of the NAMPT mRNA PubMed
tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC117256, DKFZp666B131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
enables identical protein binding IPI
Inferred from Physical Interaction
more info
enables nicotinamide phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables nicotinamide phosphoribosyltransferase activity TAS
Traceable Author Statement
more info
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
located_in cytosol TAS
Traceable Author Statement
more info
located_in extracellular exosome HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
nicotinamide phosphoribosyltransferase
pre-B cell-enhancing factor
pre-B-cell colony-enhancing factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005746.3NP_005737.1  nicotinamide phosphoribosyltransferase precursor

    See identical proteins and their annotated locations for NP_005737.1

    Status: REVIEWED

    Source sequence(s)
    AC007032, AI299587, BC106046, U02020
    Consensus CDS
    ENSP00000222553.3, ENST00000222553.8
    Conserved Domains (1) summary
    PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    106248298..106284983 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182790.1: Suppressed sequence

    NM_182790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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