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TRAP1 TNF receptor associated protein 1 [ Homo sapiens (human) ]

Gene ID: 10131, updated on 4-Nov-2018

Summary

Official Symbol
TRAP1provided by HGNC
Official Full Name
TNF receptor associated protein 1provided by HGNC
Primary source
HGNC:HGNC:16264
See related
Ensembl:ENSG00000126602 MIM:606219; Vega:OTTHUMG00000129427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP75; HSP 75; HSP90L; TRAP-1
Summary
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues See more
Orthologs

Genomic context

See TRAP1 in Genome Data Viewer
Location:
16p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (3658037..3717597, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3708038..3767598, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929732 Neighboring gene uncharacterized LOC105371060 Neighboring gene NLR family CARD domain containing 3 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene deoxyribonuclease 1 Neighboring gene CREB binding protein Neighboring gene uncharacterized LOC102724927

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of TNF receptor-associated protein 1 (TRAP1; HSP90L; HSP75) in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
heat shock protein 75 kDa, mitochondrial
Names
TNFR-associated protein 1
testicular tissue protein Li 209
tumor necrosis factor type 1 receptor-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033088.1 RefSeqGene

    Range
    5001..64561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272049.1NP_001258978.1  heat shock protein 75 kDa, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC006111, AK223205, AK299127, DB452880
    Consensus CDS
    CCDS61824.1
    UniProtKB/Swiss-Prot
    Q12931
    UniProtKB/TrEMBL
    Q53FS6
    Related
    ENSP00000442070.1, OTTHUMP00000257589, ENST00000538171.5, OTTHUMT00000438778
    Conserved Domains (3) summary
    PRK05218
    Location:34649
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:210648
    HSP90; Hsp90 protein
    pfam02518
    Location:60205
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
  2. NM_016292.2NP_057376.2  heat shock protein 75 kDa, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_057376.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF154108, BC018950, DB452880
    Consensus CDS
    CCDS10508.1
    UniProtKB/Swiss-Prot
    Q12931
    UniProtKB/TrEMBL
    A0A140VJY2
    Related
    ENSP00000246957.5, OTTHUMP00000159796, ENST00000246957.9, OTTHUMT00000251586
    Conserved Domains (1) summary
    PRK05218
    Location:87702
    PRK05218; heat shock protein 90; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    3658037..3717597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522345.2XP_011520647.1  heat shock protein 75 kDa, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011520647.1

    Related
    ENSP00000458166.1, OTTHUMP00000257588, ENST00000575671.5
    Conserved Domains (3) summary
    PRK05218
    Location:2562
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:123561
    HSP90; Hsp90 protein
    pfam02518
    Location:2118
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
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