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DNAL4 dynein axonemal light chain 4 [ Homo sapiens (human) ]

Gene ID: 10126, updated on 24-Nov-2020

Summary

Official Symbol
DNAL4provided by HGNC
Official Full Name
dynein axonemal light chain 4provided by HGNC
Primary source
HGNC:HGNC:2955
See related
Ensembl:ENSG00000100246 MIM:610565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRMV3; PIG27
Summary
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]
Expression
Broad expression in testis (RPKM 25.2), thyroid (RPKM 13.3) and 25 other tissues See more
Orthologs

Genomic context

See DNAL4 in Genome Data Viewer
Location:
22q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (38778508..38794143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39174513..39190161, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene GTP binding protein 1 Neighboring gene peroxiredoxin 3 pseudogene 1 Neighboring gene Sad1 and UNC84 domain containing 2 Neighboring gene neuronal pentraxin receptor Neighboring gene chromobox 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available
Mirror movements 3
MedGen: C4015124 OMIM: 616059 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule motor activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
microtubule-based movement TAS
Traceable Author Statement
more info
 
positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dynein light chain 4, axonemal
Names
dynein light chain, outer arm 4
dynein, axonemal, light polypeptide 4
proliferation-inducing gene 27
proliferation-inducing protein 27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041804.1 RefSeqGene

    Range
    5014..20649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005740.3NP_005731.1  dynein light chain 4, axonemal

    See identical proteins and their annotated locations for NP_005731.1

    Status: REVIEWED

    Source sequence(s)
    AL035366
    Consensus CDS
    CCDS13979.1
    UniProtKB/Swiss-Prot
    O96015
    Related
    ENSP00000216068.4, ENST00000216068.9
    Conserved Domains (1) summary
    pfam01221
    Location:20103
    Dynein_light; Dynein light chain type 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    38778508..38794143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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