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ARL4C ADP ribosylation factor like GTPase 4C [ Homo sapiens (human) ]

Gene ID: 10123, updated on 1-Jun-2020

Summary

Official Symbol
ARL4Cprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 4Cprovided by HGNC
Primary source
HGNC:HGNC:698
See related
Ensembl:ENSG00000188042 MIM:604787
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAK; ARL7
Summary
ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 30.2), spleen (RPKM 30.0) and 20 other tissues See more
Orthologs

Genomic context

See ARL4C in Genome Data Viewer
Location:
2q37.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (234493041..234497081, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (235401685..235405721, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1891 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 9 Neighboring gene CRISPRi-validated cis-regulatory element chr2.7113 Neighboring gene uncharacterized LOC105373936

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
NHGRI GWA Catalog
Genome-wide association study of pancreatic cancer in Japanese population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytic recycling IDA
Inferred from Direct Assay
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 4C
Names
ADP ribosylation factor-like protein 7
ADP-ribosylation factor-like 4C
ADP-ribosylation factor-like 7
ADP-ribosylation factor-like protein LAK

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282431.2NP_001269360.1  ADP-ribosylation factor-like protein 4C isoform 1

    See identical proteins and their annotated locations for NP_001269360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AC105145, AJ579850, BC089043
    Consensus CDS
    CCDS63169.1
    UniProtKB/Swiss-Prot
    P56559
    Related
    ENSP00000339754.3, ENST00000339728.6
    Conserved Domains (1) summary
    cd04152
    Location:11192
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  2. NM_005737.3NP_005728.2  ADP-ribosylation factor-like protein 4C isoform 2

    See identical proteins and their annotated locations for NP_005728.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional internal segment which results in alternate stop codon compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    BC001051, BM541491, BM904613, BU844902, CA413100, CD358707, Y17804
    Consensus CDS
    CCDS2512.1
    UniProtKB/Swiss-Prot
    P56559
    UniProtKB/TrEMBL
    A0A024R4C5
    Related
    ENSP00000375057.2, ENST00000390645.2
    Conserved Domains (1) summary
    cd04152
    Location:11192
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    234493041..234497081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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