U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tra2a transformer 2 alpha [ Mus musculus (house mouse) ]

Gene ID: 101214, updated on 6-Jun-2024

Summary

Official Symbol
Tra2aprovided by MGI
Official Full Name
transformer 2 alphaprovided by MGI
Primary source
MGI:MGI:1933972
See related
Ensembl:ENSMUSG00000029817 AllianceGenome:MGI:1933972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mAWMS1; Tra2alpha; TRA2-alpha; TRA-2 alpha; 1500010G04Rik; G430041M01Rik
Summary
Enables identical protein binding activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; olfactory epithelium; and retina. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 66.1), CNS E14 (RPKM 56.3) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tra2a in Genome Data Viewer
Location:
6 B2.3; 6 23.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49220855..49241182, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49243921..49264248, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_15813 Neighboring gene predicted gene, 18010 Neighboring gene RIKEN cDNA D030074P21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:49158708-49158891 Neighboring gene STARR-positive B cell enhancer mm9_chr6:49186372-49186673 Neighboring gene STARR-positive B cell enhancer mm9_chr6:49214021-49214322 Neighboring gene STARR-seq mESC enhancer starr_15823 Neighboring gene STARR-seq mESC enhancer starr_15824 Neighboring gene STARR-seq mESC enhancer starr_15825 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene coiled-coil domain containing 126

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transformer-2 protein homolog alpha
Names
nuclear transformer-2 alpha
transformer 2 alpha homolog
transformer-2 protein homolog A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347209.2NP_001334138.1  transformer-2 protein homolog alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Consensus CDS
    CCDS85044.1
    UniProtKB/Swiss-Prot
    Q6PFR5
    UniProtKB/TrEMBL
    A0A0N4SVC2
    Related
    ENSMUSP00000145039.2, ENSMUST00000204189.3
    Conserved Domains (1) summary
    cd12363
    Location:116195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
  2. NM_001362188.2NP_001349117.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Conserved Domains (1) summary
    cd12363
    Location:1796
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
  3. NM_001406117.1NP_001393046.1  transformer-2 protein homolog alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  4. NM_001406118.1NP_001393047.1  transformer-2 protein homolog alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  5. NM_001406119.1NP_001393048.1  transformer-2 protein homolog alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  6. NM_001406120.1NP_001393049.1  transformer-2 protein homolog alpha isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  7. NM_001406121.1NP_001393050.1  transformer-2 protein homolog alpha isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  8. NM_001406122.1NP_001393051.1  transformer-2 protein homolog alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  9. NM_001406123.1NP_001393052.1  transformer-2 protein homolog alpha isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  10. NM_001406124.1NP_001393053.1  transformer-2 protein homolog alpha isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  11. NM_001406125.1NP_001393054.1  transformer-2 protein homolog alpha isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
    Conserved Domains (1) summary
    cd12363
    Location:116195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
  12. NM_001406126.1NP_001393055.1  transformer-2 protein homolog alpha isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  13. NM_001406127.1NP_001393056.1  transformer-2 protein homolog alpha isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  14. NM_001406128.1NP_001393057.1  transformer-2 protein homolog alpha isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  15. NM_001406129.1NP_001393058.1  transformer-2 protein homolog alpha isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  16. NM_001406130.1NP_001393059.1  transformer-2 protein homolog alpha isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  17. NM_001406131.1NP_001393060.1  transformer-2 protein homolog alpha isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  18. NM_001406132.1NP_001393061.1  transformer-2 protein homolog alpha isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  19. NM_001406133.1NP_001393062.1  transformer-2 protein homolog alpha isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
    Conserved Domains (1) summary
    cd12363
    Location:116195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
  20. NM_001406134.1NP_001393063.1  transformer-2 protein homolog alpha isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  21. NM_001406135.1NP_001393064.1  transformer-2 protein homolog alpha isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  22. NM_001406136.1NP_001393065.1  transformer-2 protein homolog alpha isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  23. NM_001406137.1NP_001393066.1  transformer-2 protein homolog alpha isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  24. NM_001406138.1NP_001393067.1  transformer-2 protein homolog alpha isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  25. NM_001406139.1NP_001393068.1  transformer-2 protein homolog alpha isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  26. NM_001406140.1NP_001393069.1  transformer-2 protein homolog alpha isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  27. NM_001406141.1NP_001393070.1  transformer-2 protein homolog alpha isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  28. NM_001406142.1NP_001393071.1  transformer-2 protein homolog alpha isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  29. NM_001406143.1NP_001393072.1  transformer-2 protein homolog alpha isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  30. NM_001406144.1NP_001393073.1  transformer-2 protein homolog alpha isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC158667
    UniProtKB/Swiss-Prot
    Q6PFR5
  31. NM_001406145.1NP_001393074.1  transformer-2 protein homolog alpha isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC158667
  32. NM_001406146.1NP_001393075.1  transformer-2 protein homolog alpha isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC158667
  33. NM_001406147.1NP_001393076.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
  34. NM_001406149.1NP_001393078.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
  35. NM_001406150.1NP_001393079.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
  36. NM_001406151.1NP_001393080.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
  37. NM_001406152.1NP_001393081.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
  38. NM_001406153.1NP_001393082.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
  39. NM_001406154.1NP_001393083.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667
  40. NM_001406155.1NP_001393084.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667
  41. NM_001406156.1NP_001393085.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667
  42. NM_001406157.1NP_001393086.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667
  43. NM_001406158.1NP_001393087.1  transformer-2 protein homolog alpha isoform 36

    Status: VALIDATED

    Source sequence(s)
    AC158667
  44. NM_001406159.1NP_001393088.1  transformer-2 protein homolog alpha isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC158667
  45. NM_001406160.1NP_001393089.1  transformer-2 protein homolog alpha isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC158667
  46. NM_001406161.1NP_001393090.1  transformer-2 protein homolog alpha isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC158667
  47. NM_198102.3NP_932770.2  transformer-2 protein homolog alpha isoform 1

    See identical proteins and their annotated locations for NP_932770.2

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Consensus CDS
    CCDS39486.1
    UniProtKB/Swiss-Prot
    Q6PFR5
    UniProtKB/TrEMBL
    E9QP00
    Related
    ENSMUSP00000031841.8, ENSMUST00000031841.9
    Conserved Domains (1) summary
    cd12363
    Location:116195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49220855..49241182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505243.1XP_006505306.1  transformer-2 protein homolog alpha isoform X4

    UniProtKB/Swiss-Prot
    Q6PFR5
    Conserved Domains (1) summary
    cd12363
    Location:145222
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
  2. XM_036165704.1XP_036021597.1  transformer-2 protein homolog alpha isoform X7

    Conserved Domains (1) summary
    cd12363
    Location:1796
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins