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Tada3 transcriptional adaptor 3 [ Mus musculus (house mouse) ]

Gene ID: 101206, updated on 5-Mar-2024

Summary

Official Symbol
Tada3provided by MGI
Official Full Name
transcriptional adaptor 3provided by MGI
Primary source
MGI:MGI:1915724
See related
Ensembl:ENSMUSG00000048930 AllianceGenome:MGI:1915724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADA3; Tada3l; 1110004B19Rik
Summary
Enables nuclear receptor coactivator activity. Acts upstream of or within mitotic cell cycle; regulation of protein modification process; and regulation of protein stability. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in eye; ureteric tip; and ureteric trunk. Orthologous to human TADA3 (transcriptional adaptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.2), CNS E18 (RPKM 14.6) and 28 other tissues See more
Orthologs
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Genomic context

See Tada3 in Genome Data Viewer
Location:
6 E3; 6 52.75 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113343594..113354799, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113366633..113377838, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 8-oxoguanine DNA-glycosylase 1 Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113327864-113328099 Neighboring gene actin related protein 2/3 complex, subunit 4 Neighboring gene tubulin tyrosine ligase-like family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1706 Neighboring gene RNA pseudouridylate synthase domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcriptional adapter 3
Names
ADA3 homolog
ADA3-like protein
mADA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372392.1NP_001359321.1  transcriptional adapter 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Related
    ENSMUSP00000043363.3, ENSMUST00000043333.9
    Conserved Domains (1) summary
    pfam10198
    Location:317430
    Ada3; Histone acetyltransferases subunit 3
  2. NM_001372393.1NP_001359322.1  transcriptional adapter 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Conserved Domains (1) summary
    pfam10198
    Location:317430
    Ada3; Histone acetyltransferases subunit 3
  3. NM_133932.3NP_598693.1  transcriptional adapter 3 isoform 1

    See identical proteins and their annotated locations for NP_598693.1

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Consensus CDS
    CCDS20416.1
    UniProtKB/Swiss-Prot
    Q8CIH4, Q8K289, Q8R0L9, Q8R5E3, Q9CTJ0
    Related
    ENSMUSP00000032410.8, ENSMUST00000032410.14
    Conserved Domains (1) summary
    pfam10198
    Location:309422
    Ada3; Histone acetyltransferases subunit 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113343594..113354799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165703.1XP_036021596.1  transcriptional adapter 3 isoform X1

    Conserved Domains (1) summary
    pfam10198
    Location:317430
    Ada3; Histone acetyltransferases subunit 3