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ACTR1B actin related protein 1B [ Homo sapiens (human) ]

Gene ID: 10120, updated on 10-Oct-2020

Summary

Official Symbol
ACTR1Bprovided by HGNC
Official Full Name
actin related protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:168
See related
Ensembl:ENSG00000115073 MIM:605144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC3; ARP1B; CTRN2
Summary
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in spleen (RPKM 24.2), brain (RPKM 24.1) and 25 other tissues See more
Orthologs

Genomic context

See ACTR1B in Genome Data Viewer
Location:
2q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (97655939..97664044, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98272402..98280561, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UBTF like 6 (pseudogene) Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene chromosome 2 open reading frame 92 Neighboring gene RNA, U4 small nuclear 8, pseudogene Neighboring gene zeta chain of T cell receptor associated protein kinase 70

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dynactin complex TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
beta-centractin
Names
ARP1 actin related protein 1 homolog B
ARP1 actin-related protein 1 homolog B, centractin beta
centractin beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005735.4NP_005726.1  beta-centractin

    See identical proteins and their annotated locations for NP_005726.1

    Status: REVIEWED

    Source sequence(s)
    AC017099, BC010090, X82207
    Consensus CDS
    CCDS2033.1
    UniProtKB/Swiss-Prot
    P42025
    Related
    ENSP00000289228.5, ENST00000289228.7
    Conserved Domains (1) summary
    cl17037
    Location:5376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    97655939..97664044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263854.5XP_005263911.1  beta-centractin isoform X1

    See identical proteins and their annotated locations for XP_005263911.1

    Conserved Domains (2) summary
    pfam00022
    Location:1302
    Actin; Actin
    cl17037
    Location:1302
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_017003116.1XP_016858605.1  beta-centractin isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:2332
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
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