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Pot1a protection of telomeres 1A [ Mus musculus (house mouse) ]

Gene ID: 101185, updated on 12-Aug-2019

Summary

Official Symbol
Pot1aprovided by MGI
Official Full Name
protection of telomeres 1Aprovided by MGI
Primary source
MGI:MGI:2141503
See related
Ensembl:ENSMUSG00000029676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pot1; AI851169; 1500031H18Rik
Expression
Ubiquitous expression in liver E14 (RPKM 7.1), liver E14.5 (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See Pot1a in Genome Data Viewer
Location:
6; 6 A3.1
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (25743940..25809277, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (25693735..25759226, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene G protein-coupled receptor 37 Neighboring gene predicted gene, 20756 Neighboring gene PCNA-associated factor pseudogene Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
8-hydroxy-2'-deoxyguanosine DNA binding ISO
Inferred from Sequence Orthology
more info
 
DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
G-rich single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomerase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
telomeric D-loop binding ISO
Inferred from Sequence Orthology
more info
 
telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
chromosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
telomere assembly ISO
Inferred from Sequence Orthology
more info
 
telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere capping ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
telomeric D-loop disassembly ISO
Inferred from Sequence Orthology
more info
 
NOT telomeric loop formation IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT telomeric loop formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nuclear telomere cap complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear telomere cap complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear telomere cap complex ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
shelterin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protection of telomeres protein 1
Names
POT1-like telomere end-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133931.5NP_598692.1  protection of telomeres protein 1

    See identical proteins and their annotated locations for NP_598692.1

    Status: VALIDATED

    Source sequence(s)
    AC153888, AC158683
    Consensus CDS
    CCDS39442.1
    UniProtKB/Swiss-Prot
    Q91WC1
    Related
    ENSMUSP00000110986.1, ENSMUST00000115330.7
    Conserved Domains (2) summary
    smart00976
    Location:11141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    pfam16686
    Location:153299
    POT1PC; ssDNA-binding domain of telomere protection protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    25743940..25809277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504956.2XP_006505019.1  protection of telomeres protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505019.1

    Conserved Domains (2) summary
    smart00976
    Location:182
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    pfam16686
    Location:94240
    POT1PC; ssDNA-binding domain of telomere protection protein
  2. XM_006504955.2XP_006505018.1  protection of telomeres protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505018.1

    Conserved Domains (2) summary
    smart00976
    Location:182
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    pfam16686
    Location:94240
    POT1PC; ssDNA-binding domain of telomere protection protein

RNA

  1. XR_377283.3 RNA Sequence

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