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FEM1B fem-1 homolog B [ Homo sapiens (human) ]

Gene ID: 10116, updated on 16-Aug-2021

Summary

Official Symbol
FEM1Bprovided by HGNC
Official Full Name
fem-1 homolog Bprovided by HGNC
Primary source
HGNC:HGNC:3649
See related
Ensembl:ENSG00000169018 MIM:613539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F1AA; F1A-ALPHA; FEM1-beta
Summary
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in brain (RPKM 18.1), endometrium (RPKM 14.9) and 25 other tissues See more
Orthologs
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Genomic context

See FEM1B in Genome Data Viewer
Location:
15q23
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (68277745..68295862)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68570083..68588200)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CLN6 transmembrane ER protein Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 40 Neighboring gene integrin subunit alpha 11 Neighboring gene uncharacterized LOC105370873

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0396, DKFZp451E0710, DKFZp686G22120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables death receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables death receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein fem-1 homolog B
Names
FEM-1-like death receptor binding protein
fem-1-like death receptor-binding protein alpha
fem-1-like in apoptotic pathway protein alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015322.5NP_056137.1  protein fem-1 homolog B

    See identical proteins and their annotated locations for NP_056137.1

    Status: REVIEWED

    Source sequence(s)
    AB007856, AC021553, AC107871, BC010122, BF112021
    Consensus CDS
    CCDS10228.1
    UniProtKB/Swiss-Prot
    Q9UK73
    Related
    ENSP00000307298.4, ENST00000306917.5
    Conserved Domains (3) summary
    PHA03095
    Location:475613
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:87118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:158247
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    68277745..68295862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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