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HIPK3 homeodomain interacting protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 10114, updated on 2-Oct-2018

Summary

Official Symbol
HIPK3provided by HGNC
Official Full Name
homeodomain interacting protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:4915
See related
Ensembl:ENSG00000110422 MIM:604424; Vega:OTTHUMG00000132269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKY; YAK1; DYRK6; FIST3
Expression
Ubiquitous expression in fat (RPKM 29.7), gall bladder (RPKM 21.4) and 25 other tissues See more
Orthologs

Genomic context

See HIPK3 in Genome Data Viewer
Location:
11p13
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (33256672..33357023)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33274406..33378569)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CSTF3 divergent transcript Neighboring gene ribosomal protein L29 pseudogene 23 Neighboring gene ribosomal protein S24 pseudogene 15 Neighboring gene KIAA1549 like Neighboring gene uncharacterized LOC105376617 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene CD59 molecule (CD59 blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
homeodomain-interacting protein kinase 3
Names
ANPK
FIST
androgen receptor-interacting nuclear protein kinase
fas-interacting serine/threonine-protein kinase
homolog of protein kinase YAK1
NP_001041665.1
NP_001265091.1
NP_001265092.1
NP_005725.3
XP_005252786.1
XP_016872565.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048200.2NP_001041665.1  homeodomain-interacting protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001041665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AK315277, AL122015, BX117467, DR000092, HY053621
    Consensus CDS
    CCDS41634.1
    UniProtKB/Swiss-Prot
    Q9H422
    Related
    ENSP00000368301.3, OTTHUMP00000163107, ENST00000379016.7, OTTHUMT00000255359
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
  2. NM_001278162.1NP_001265091.1  homeodomain-interacting protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001265091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AK293009, AK315277, AL122015, BX117467
    Consensus CDS
    CCDS41634.1
    UniProtKB/TrEMBL
    A8KAE4
    Related
    ENSP00000398241.1, ENST00000456517.2
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
  3. NM_001278163.1NP_001265092.1  homeodomain-interacting protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001265092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AK315277, AL122015, BX117467
    Consensus CDS
    CCDS41634.1
    UniProtKB/Swiss-Prot
    Q9H422
    Related
    ENSP00000431710.1, OTTHUMP00000232315, ENST00000525975.5, OTTHUMT00000388661
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
  4. NM_005734.4NP_005725.3  homeodomain-interacting protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_005725.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF004849, AL122015, BX117467, DR000092, HY053621, Y09306
    Consensus CDS
    CCDS7884.1
    UniProtKB/Swiss-Prot
    Q9H422
    Related
    ENSP00000304226.4, OTTHUMP00000163106, ENST00000303296.8, OTTHUMT00000255358
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    33256672..33357023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252729.3XP_005252786.1  homeodomain-interacting protein kinase 3 isoform X1

    See identical proteins and their annotated locations for XP_005252786.1

    UniProtKB/Swiss-Prot
    Q9H422
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
  2. XM_017017076.1XP_016872565.1  homeodomain-interacting protein kinase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9H422
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
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