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B4GALNT2 beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group) [ Ovis aries (sheep) ]

Gene ID: 101119323, updated on 8-Mar-2024

Summary

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Gene symbol
B4GALNT2
Gene description
beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group)
See related
EnsemblRapid:ENSOARG00020022870
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See B4GALNT2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (37116929..37193768, complement)

Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma transducin 2 Neighboring gene transfer RNA glutamine (anticodon UUG) Neighboring gene uncharacterized LOC132657345 Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene ezrin-like Neighboring gene insulin like growth factor 2 mRNA binding protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The high prolificacy of D'man sheep is associated with the segregation of the FecL(L) mutation in the B4GALNT2 gene. Ben Jemaa S, et al. Reprod Domest Anim, 2019 Mar. PMID 30561778
  2. The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary. Drouilhet L, et al. PLoS Genet, 2013. PMID 24086150, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this study, we have highlighted the segregation of the FecL(L) mutation within the B4GALNT2 gene in North African sheep breeds and notably in the highly prolific D'man breed. The presence of the FecL(L) polymorphism in both D'man and Lacaune breeds argues for an ancestral origin of this mutation and brings an answer to the old question of the genetic determinism of the extreme prolificacy of the D'man ewes.
    Title: The high prolificacy of D'man sheep is associated with the segregation of the FecL(L) mutation in the B4GALNT2 gene.
  2. Specific ovarian protein glycosylation by B4GALNT2 is proposed as a new mechanism of ovulation rate regulation in sheep, and could contribute to open new fields of investigation to understand female infertility pathogenesis.
    Title: The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylgalactosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in UDP-N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid glycosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-1,4 N-acetylgalactosaminyltransferase 2
NP_001305005.1
XP_042111143.1
XP_060250676.1
XP_060250678.1
XP_060250679.1
XP_060250680.1
XP_060250681.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318076.1 → NP_001305005.1  beta-1,4 N-acetylgalactosaminyltransferase 2

    Status: PROVISIONAL

    Source sequence(s)
    KC175557
    UniProtKB/TrEMBL
    A0A6P3CYR5, A0A836CZB0, M1LF60
    Related
    ENSOARP00020029428.1, ENSOART00020035606.2
    Conserved Domains (2) summary
    pfam00535
    Location:264 → 370
    Glycos_transf_2; Glycosyl transferase family 2
    cl11394
    Location:322 → 434
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    37116929..37193768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060394698.1 → XP_060250681.1  beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X2

  2. XM_042255209.2 → XP_042111143.1  beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X3

    UniProtKB/TrEMBL
    A0A836CZB0
    Conserved Domains (1) summary
    cd00761
    Location:263 → 355
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. XM_060394696.1 → XP_060250679.1  beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X2

  4. XM_060394697.1 → XP_060250680.1  beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X2

  5. XM_060394693.1 → XP_060250676.1  beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X1

  6. XM_060394695.1 → XP_060250678.1  beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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