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PLA2G6 phospholipase A2 group VI [ Ovis aries (sheep) ]

Gene ID: 101103799, updated on 8-Mar-2024

Summary

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Gene symbol
PLA2G6
Gene description
phospholipase A2 group VI
See related
EnsemblRapid:ENSOARG00020008751
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See PLA2G6 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (215721878..215782683, complement)

Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 8 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene MAF bZIP transcription factor F Neighboring gene transmembrane protein 184B Neighboring gene uncharacterized LOC132659502

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Ovis aries Rambouillet Genome sequencing and assembly
  • BioProject: PRJNA414087
  • Analysis date: Thu Jan 09 10:41:41 2025

Bibliography

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Related articles in PubMed

  1. Compound heterozygous PLA2G6 loss-of-function variants in Swaledale sheep with neuroaxonal dystrophy. Letko A, et al. Mol Genet Genomics, 2021 Jan. PMID 33159255, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Compound heterozygous PLA2G6 loss-of-function variants in Swaledale sheep with neuroaxonal dystrophy.
    Title: Compound heterozygous PLA2G6 loss-of-function variants in Swaledale sheep with neuroaxonal dystrophy.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiolipin acyl-chain remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
85/88 kDa calcium-independent phospholipase A2
Names
phospholipase A2, group VI (cytosolic, calcium-independent)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    215721878..215782683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027968104.2 → XP_027823905.1  85/88 kDa calcium-independent phospholipase A2 isoform X7

    UniProtKB/TrEMBL
    A0A6P7DZ17, A0A836ABE9, W5Q0J5
    Related
    ENSOARP00020054862.1, ENSOART00020047678.1

  2. XM_012175630.4 → XP_012031020.2  85/88 kDa calcium-independent phospholipase A2 isoform X5

    UniProtKB/TrEMBL
    W5Q0J1
    Related
    ENSOARP00020011371.2, ENSOART00020013805.2
    Conserved Domains (4) summary
    cd07212
    Location:479 → 792
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02875
    Location:220 → 412
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:291 → 380
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_042247721.1 → XP_042103655.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

    UniProtKB/TrEMBL
    W5Q0J1
    Conserved Domains (4) summary
    cd07212
    Location:479 → 792
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02875
    Location:220 → 412
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:291 → 380
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_042247720.1 → XP_042103654.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    UniProtKB/TrEMBL
    W5Q0J1
    Related
    ENSOARP00020052687.1, ENSOART00020051277.1
    Conserved Domains (3) summary
    cd07212
    Location:520 → 833
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    sd00045
    Location:327 → 355
    ANK; ANK repeat [structural motif]
    cl39094
    Location:194 → 444
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_012175634.5 → XP_012031024.3  85/88 kDa calcium-independent phospholipase A2 isoform X4

    UniProtKB/TrEMBL
    A0A836ABE9
    Conserved Domains (3) summary
    cd07212
    Location:517 → 830
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    sd00045
    Location:377 → 405
    ANK; ANK repeat [structural motif]
    cl39094
    Location:244 → 481
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_004006987.6 → XP_004007036.4  85/88 kDa calcium-independent phospholipase A2 isoform X1

    UniProtKB/TrEMBL
    W5Q0J1
    Related
    ENSOARP00020048207.1, ENSOART00020052744.1
    Conserved Domains (3) summary
    cd07212
    Location:570 → 883
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    sd00045
    Location:377 → 405
    ANK; ANK repeat [structural motif]
    cl39094
    Location:244 → 494
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_042247719.2 → XP_042103653.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

    UniProtKB/TrEMBL
    W5Q0J1
    Conserved Domains (3) summary
    cd07212
    Location:531 → 844
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    sd00045
    Location:338 → 366
    ANK; ANK repeat [structural motif]
    cl39094
    Location:205 → 455
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_012175636.5 → XP_012031026.3  85/88 kDa calcium-independent phospholipase A2 isoform X6

    Conserved Domains (3) summary
    sd00045
    Location:377 → 405
    ANK; ANK repeat [structural motif]
    cl11396
    Location:570 → 716
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl39094
    Location:244 → 494
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_060414269.1 → XP_060270252.1  85/88 kDa calcium-independent phospholipase A2 isoform X8

RNA

  1. XR_006059481.2 RNA Sequence

  2. XR_006059480.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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