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SGK2 serum/glucocorticoid regulated kinase 2 [ Homo sapiens (human) ]

Gene ID: 10110, updated on 23-Nov-2023

Summary

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Official Symbol
SGK2provided by HGNC
Official Full Name
serum/glucocorticoid regulated kinase 2provided by HGNC
Primary source
HGNC:HGNC:13900
See related
Ensembl:ENSG00000101049 MIM:607589; AllianceGenome:HGNC:13900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H-SGK2; dJ138B7.2
Summary
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Expression
Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues See more
Orthologs
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Genomic context

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See SGK2 in Genome Data Viewer
Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (43559027..43585627)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45292229..45318829)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42187667..42214267)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1251, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12927 Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene transmembrane protein 14C-like Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42173308-42173524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42236005-42236846 Neighboring gene intraflagellar transport 52 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42266543-42266756 Neighboring gene ribosomal protein L27a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells. Ranzuglia V, et al. Oncogene, 2020 Oct. PMID 32848212, Free PMC Article
  2. SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells. Liu Y, et al. Eur J Surg Oncol, 2020 Oct. PMID 32565024
  3. SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation. Liu Y, et al. Eur Rev Med Pharmacol Sci, 2019 Apr. PMID 31002126
  4. Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis. Gotoh S, et al. Sci Rep, 2015 Sep 22. PMID 26392083, Free PMC Article
  5. Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies. Náray-Fejes-Tóth A, et al. Mol Cell Endocrinol, 2004 Mar 31. PMID 15134818

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
    Title: SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
  2. SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells.
    Title: SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells.
  3. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.
    Title: Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.
  4. SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.
    Title: SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.
  5. Loss of the paternally derived allele of the imprinted SGK2 gene is associated with Shwachman-Diamond syndrome.
    Title: Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.
  6. These findings suggest that SGK2 promotes hepatocellular carcinoma progression and mediates glycogen synthase kinase 3 beta/beta-catenin signaling in hepatocellular carcinoma cells.
    Title: SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.
  7. SGK2 stimulated hOAT4 transport activity by abrogating the inhibitory effect of Nedd4-2 on the transporter.
    Title: Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.
  8. Activation of hepatocyte pregnane X receptor is mediated through serum- and glucocorticoid-regulated kinase (SGK)2.
    Title: Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.
  9. Glucocorticoid inducible kinase isoforms SGK1-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo.
    Title: The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.
  10. All three members of the SGK family of kinases SGK1-3 and protein kinase B stimulate the slowly activating K(+) channel KCNE1/KCNQ1. The kinases may thus participate in the regulation of KCNE1-dependent transport and excitability.
    Title: Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables sodium channel regulator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transporter activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell growth TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Sgk2
Names
SGK2, serine/threonine kinase 2
NP_001186193.1
NP_057360.3
NP_733794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029448.2 RefSeqGene

    Range
    5033..31633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1050

mRNA and Protein(s)

  1. NM_001199264.2 → NP_001186193.1  serine/threonine-protein kinase Sgk2

    See identical proteins and their annotated locations for NP_001186193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    BC065511, DA244897
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
    UniProtKB/TrEMBL
    A8K0N1
    Related
    ENSP00000392795.3, ENST00000423407.7
    Conserved Domains (1) summary
    cd05603
    Location:39 → 359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

  2. NM_016276.5 → NP_057360.3  serine/threonine-protein kinase Sgk2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest transcript. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AF186470, BC065511, CD627734, Z98752
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
    UniProtKB/TrEMBL
    A8K0N1
    Related
    ENSP00000340608.5, ENST00000341458.10
    Conserved Domains (1) summary
    cd05603
    Location:39 → 359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

  3. NM_170693.3 → NP_733794.1  serine/threonine-protein kinase Sgk2

    See identical proteins and their annotated locations for NP_733794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AF169034, BC065511, DB183229
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
    UniProtKB/TrEMBL
    A8K0N1
    Related
    ENSP00000362192.1, ENST00000373100.7
    Conserved Domains (1) summary
    cd05603
    Location:39 → 359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    43559027..43585627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    45292229..45318829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBY8.2 GenPept UniProtKB/Swiss-Prot:Q9HBY8

Gene LinkOut

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