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SGK2 serum/glucocorticoid regulated kinase 2 [ Homo sapiens (human) ]

Gene ID: 10110, updated on 5-Sep-2021

Summary

Official Symbol
SGK2provided by HGNC
Official Full Name
serum/glucocorticoid regulated kinase 2provided by HGNC
Primary source
HGNC:HGNC:13900
See related
Ensembl:ENSG00000101049 MIM:607589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H-SGK2; dJ138B7.2
Summary
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Expression
Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues See more
Orthologs
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Genomic context

See SGK2 in Genome Data Viewer
Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (43559027..43585627)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42187667..42214267)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1251, pseudogene Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene transmembrane protein 14C pseudogene Neighboring gene intraflagellar transport 52 Neighboring gene ribosomal protein L27a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium channel regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
enables sodium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Sgk2
Names
SGK2, serine/threonine kinase 2
NP_001186193.1
NP_057360.3
NP_733794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029448.2 RefSeqGene

    Range
    5033..31633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1050

mRNA and Protein(s)

  1. NM_001199264.2NP_001186193.1  serine/threonine-protein kinase Sgk2

    See identical proteins and their annotated locations for NP_001186193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    BC065511, DA244897
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q9HBY8
    Related
    ENSP00000392795.3, ENST00000423407.7
    Conserved Domains (1) summary
    cd05603
    Location:39359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
  2. NM_016276.5NP_057360.3  serine/threonine-protein kinase Sgk2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest transcript. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AF186470, BC065511, CD627734, Z98752
    Consensus CDS
    CCDS13320.1
    Related
    ENSP00000340608.4, ENST00000341458.9
    Conserved Domains (1) summary
    cd05603
    Location:39359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
  3. NM_170693.3NP_733794.1  serine/threonine-protein kinase Sgk2

    See identical proteins and their annotated locations for NP_733794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AF169034, BC065511, DB183229
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q9HBY8
    Related
    ENSP00000362192.1, ENST00000373100.7
    Conserved Domains (1) summary
    cd05603
    Location:39359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    43559027..43585627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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