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TBC1D3D TBC1 domain family member 3D [ Homo sapiens (human) ]

Gene ID: 101060389, updated on 5-Aug-2022

Summary

Official Symbol
TBC1D3Dprovided by HGNC
Official Full Name
TBC1 domain family member 3Dprovided by HGNC
Primary source
HGNC:HGNC:28944
See related
Ensembl:ENSG00000274419 MIM:610807; AllianceGenome:HGNC:28944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRC17; TBC1D3; TBC1D3A; TBC1D3H
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 15.4), skin (RPKM 9.8) and 24 other tissues See more
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Genomic context

See TBC1D3D in Genome Data Viewer
Location:
17q12
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38002322..38014908)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38965106..38976061, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 2, inducible pseudogene Neighboring gene TBC1 domain family member 3L Neighboring gene uncharacterized LOC102723819 Neighboring gene TBC1 domain family member 3C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TBC1 domain family member 3D
Names
Prostate cancer gene 17 protein
Rab GTPase-activating protein PRC17
TBC1 domain family member 3
TBC1 domain family, member 3H
TRE17 alpha protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291465.2NP_001278394.1  TBC1 domain family member 3D

    See identical proteins and their annotated locations for NP_001278394.1

    Status: VALIDATED

    Source sequence(s)
    AC233968
    Consensus CDS
    CCDS74044.1
    UniProtKB/Swiss-Prot
    A0A087WVF3
    Related
    ENSP00000478426.1, ENST00000616101.5
    Conserved Domains (1) summary
    smart00164
    Location:99312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38002322..38014908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435093.1XP_047291049.1  TBC1 domain family member 3D isoform X3

    UniProtKB/Swiss-Prot
    A0A087WVF3
  2. XM_011524176.3XP_011522478.1  TBC1 domain family member 3D isoform X1

    See identical proteins and their annotated locations for XP_011522478.1

    Conserved Domains (1) summary
    smart00164
    Location:160373
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  3. XM_006722248.2XP_006722311.1  TBC1 domain family member 3D isoform X1

    See identical proteins and their annotated locations for XP_006722311.1

    Conserved Domains (1) summary
    smart00164
    Location:160373
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  4. XM_006722249.2XP_006722312.1  TBC1 domain family member 3D isoform X2

    Conserved Domains (1) summary
    smart00164
    Location:160351
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  5. XM_006722252.4XP_006722315.1  TBC1 domain family member 3D isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:99290
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  6. XM_006722253.2XP_006722316.1  TBC1 domain family member 3D isoform X5

    See identical proteins and their annotated locations for XP_006722316.1

    Conserved Domains (1) summary
    smart00164
    Location:160361
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  7. XM_017024010.3XP_016879499.1  TBC1 domain family member 3D isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    38965106..38976061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001123390.1: Suppressed sequence

    Description
    NM_001123390.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.