OPN1MW3 opsin 1, medium wave sensitive 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OPN1MW3provided by HGNC
Official Full Name: opsin 1, medium wave sensitive 3provided by HGNC
Primary source: HGNC:HGNC:51831
See related: Ensembl:ENSG00000269433 AllianceGenome:HGNC:51831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GCP; GOP; OPN1MW; OPN1MW2
Summary: Enables identical protein binding activity and photoreceptor activity. Involved in positive regulation of cytokinesis. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: Xq28

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (154257582..154271090)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X (PATCHES)	NW_003871103.3 (1691561..1705069)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480769

OPN1MW (e-PCR)
- UniSTS:506666

Opn1mw (e-PCR), detects polymorphism
- UniSTS:536456

OPN1LW (e-PCR)
- UniSTS:266927

G44366 (e-PCR)
- UniSTS:95152

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of visible light	IEA Inferred from Electronic Annotation more info
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in photoreceptor disc membrane	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: medium-wave-sensitive opsin 3

Names: Medium-wave-sensitive opsin 2; Opsin 1 cone pigments medium-wave-sensitive 2; green cone photoreceptor pigment; green-sensitive opsin; opsin 1 (cone pigments), medium-wave-sensitive 3; opsin 1 cone pigments medium-wave-sensitive 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330067.2 → NP_001316996.1 medium-wave-sensitive opsin 3

Status: VALIDATED

Source sequence(s)

AC245140

Consensus CDS

CCDS83509.1

UniProtKB/Swiss-Prot

P04001, P0DN77, P0DN78

UniProtKB/TrEMBL

B7ZLG5

Related

ENSP00000469970.1, ENST00000599405.4

Conserved Domains (2) summary

pfam00001
Location:71 → 322

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:61 → 178

7tm_4; Olfactory receptor