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TSPAN1 tetraspanin 1 [ Homo sapiens (human) ]

Gene ID: 10103, updated on 22-Jan-2023

Summary

Official Symbol
TSPAN1provided by HGNC
Official Full Name
tetraspanin 1provided by HGNC
Primary source
HGNC:HGNC:20657
See related
Ensembl:ENSG00000117472 MIM:613170; AllianceGenome:HGNC:20657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET1; TM4C; TM4SF
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 237.8), prostate (RPKM 118.0) and 10 other tissues See more
Orthologs
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Genomic context

See TSPAN1 in Genome Data Viewer
Location:
1p34.1
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46175087..46196489)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46052282..46063182)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46640759..46651634)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene P3R3URF-PIK3R3 readthrough Neighboring gene uncharacterized LOC124904171 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene uncharacterized LOC101929626 Neighboring gene PIK3R3 upstream open reading frame Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene leucine rich adaptor protein 1 Neighboring gene RAD54 like Neighboring gene leucine rich repeat containing 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle HDA PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tetraspanin-1
Names
tetraspan 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005727.4NP_005718.2  tetraspanin-1

    See identical proteins and their annotated locations for NP_005718.2

    Status: REVIEWED

    Source sequence(s)
    AF065388, AK313774, BM856468
    Consensus CDS
    CCDS530.1
    UniProtKB/Swiss-Prot
    O60635, Q5VST0
    Related
    ENSP00000361072.1, ENST00000372003.6
    Conserved Domains (1) summary
    pfam00335
    Location:7236
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46175087..46196489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421003.1XP_047276959.1  tetraspanin-1 isoform X1

  2. XM_047420922.1XP_047276878.1  tetraspanin-1 isoform X1

  3. XM_047420982.1XP_047276938.1  tetraspanin-1 isoform X1

  4. XM_047420887.1XP_047276843.1  tetraspanin-1 isoform X1

  5. XM_047420946.1XP_047276902.1  tetraspanin-1 isoform X1

  6. XM_011540460.4XP_011538762.1  tetraspanin-1 isoform X1

    Conserved Domains (2) summary
    cd03156
    Location:110212
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:7214
    Tetraspannin; Tetraspanin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46052282..46063182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)