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NOTCH2NLC notch 2 N-terminal like C [ Homo sapiens (human) ]

Gene ID: 100996717, updated on 19-Oct-2019

Summary

Official Symbol
NOTCH2NLCprovided by HGNC
Official Full Name
notch 2 N-terminal like Cprovided by HGNC
Primary source
HGNC:HGNC:53924
See related
Ensembl:ENSG00000286219 MIM:618025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N2N; NIID; NOTCH2NL; NOTCH2NLA
Expression
Ubiquitous expression in testis (RPKM 3.9), bone marrow (RPKM 2.8) and 25 other tissues See more

Genomic context

See NOTCH2NLC in Genome Data Viewer
Location:
1q21.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (149390621..149471833)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 (PATCHES) NW_003871055.3 (6200466..6279623)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SEC22 homolog B2, pseudogene Neighboring gene uncharacterized LOC105371403 Neighboring gene NBPF member 19 Neighboring gene uncharacterized LOC101060227 Neighboring gene tRNA-Asn (anticodon GTT) 25-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Potential readthrough

Included gene: NBPF19

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
notch homolog 2 N-terminal-like protein C
Names
Notch homolog 2 N-terminal-like protein A
notch homolog 2 N-terminal-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364012.2NP_001350941.1  notch homolog 2 N-terminal-like protein C isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC242842, AC242843
    Consensus CDS
    CCDS86015.1
    Related
    ENSP00000498514.1, ENST00000652191.1
    Conserved Domains (1) summary
    cd00054
    Location:143179
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. NM_001364013.1NP_001350942.1  notch homolog 2 N-terminal-like protein C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at a 5' exon compared to variant 1. This difference is predicted to result in the use of an upstream start codon and an isoform (2) with a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AC242842, AC242843
    Related
    ENSP00000499085.1, ENST00000650865.1
    Conserved Domains (1) summary
    cd00054
    Location:200236
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    149390621..149471833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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