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SPIRE1 spire type actin nucleation factor 1 [ Pan paniscus (pygmy chimpanzee) ]

Gene ID: 100995639, updated on 3-Apr-2024

Summary

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Gene symbol
SPIRE1
Gene description
spire type actin nucleation factor 1
See related
Ensembl:ENSPPAG00000034426
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan paniscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 17 NC_073266.2 (25383793..25599056)
RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 18 NC_073267.1 (11076386..11291651)

Chromosome 17 - NC_073266.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134729210 Neighboring gene centrosomal protein 76 Neighboring gene uncharacterized LOC129394611 Neighboring gene small nucleolar RNA U13 Neighboring gene high mobility group protein B3-like Neighboring gene PRELI domain containing 3A Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actin filament network formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actin nucleation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cleavage furrow formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of meiotic spindle localization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in polar body extrusion after meiotic divisions IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein spire homolog 1
Names
spire homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

  1. NC_073266.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Range
    25383793..25599056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_034944069.3 → XP_034799960.1  protein spire homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A2R9B4Z4
    Conserved Domains (6) summary
    cd15767
    Location:588 → 708
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:40 → 236
    KIND; Kinase non-catalytic C-lobe domain
    cd22065
    Location:260 → 291
    WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
    cd22078
    Location:300 → 331
    WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins
    cd22080
    Location:365 → 388
    WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1
    cd22186
    Location:334 → 356
    WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2

  2. XM_034944070.3 → XP_034799961.1  protein spire homolog 1 isoform X4

    UniProtKB/TrEMBL
    A0A2R9AZ62
    Conserved Domains (6) summary
    cd15767
    Location:574 → 694
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:40 → 236
    KIND; Kinase non-catalytic C-lobe domain
    cd22065
    Location:260 → 291
    WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
    cd22078
    Location:300 → 331
    WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins
    cd22080
    Location:365 → 388
    WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1
    cd22186
    Location:334 → 356
    WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2

  3. XM_034944067.3 → XP_034799958.1  protein spire homolog 1 isoform X1

    Conserved Domains (6) summary
    cd15767
    Location:646 → 766
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:40 → 236
    KIND; Kinase non-catalytic C-lobe domain
    cd22065
    Location:260 → 291
    WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
    cd22078
    Location:300 → 331
    WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins
    cd22080
    Location:365 → 388
    WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1
    cd22186
    Location:334 → 356
    WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2

  4. XM_034944068.3 → XP_034799959.1  protein spire homolog 1 isoform X2

    Conserved Domains (6) summary
    cd15767
    Location:632 → 752
    FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    pfam16474
    Location:40 → 236
    KIND; Kinase non-catalytic C-lobe domain
    cd22065
    Location:260 → 291
    WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
    cd22078
    Location:300 → 331
    WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins
    cd22080
    Location:365 → 388
    WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1
    cd22186
    Location:334 → 356
    WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2

  5. XM_055102545.1 → XP_054958520.1  protein spire homolog 1 isoform X6

  6. XM_055102542.1 → XP_054958517.1  protein spire homolog 1 isoform X5

  7. XM_055102546.1 → XP_054958521.1  protein spire homolog 1 isoform X7

Nucleotide Protein
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