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GPX4 glutathione peroxidase 4 [ Pan paniscus (pygmy chimpanzee) ]

Gene ID: 100990361, updated on 8-Mar-2024

Summary

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Gene symbol
GPX4
Gene description
glutathione peroxidase 4
See related
Ensembl:ENSPPAG00000039351
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan paniscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 20 NC_073269.2 (5439232..5443396)
RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 19 NC_073268.1 (4675807..4679965)

Chromosome 20 - NC_073269.2Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 7 Neighboring gene Rho GTPase activating protein 45 Neighboring gene RNA polymerase II, I and III subunit E Neighboring gene strawberry notch homolog 2 Neighboring gene high mobility group protein B2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phospholipid-hydroperoxide glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phospholipid hydroperoxide glutathione peroxidase GPX4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

  1. NC_073269.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Range
    5439232..5443396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_057300686.2 → XP_057156669.1  phospholipid hydroperoxide glutathione peroxidase GPX4 isoform X3

  2. XM_014342393.4 → XP_014197879.1  phospholipid hydroperoxide glutathione peroxidase GPX4 isoform X2

    UniProtKB/TrEMBL
    A0A2R9BTJ8
    Related
    ENSPPAP00000032993.1
    Conserved Domains (1) summary
    cd00340
    Location:40 → 193
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

  3. XM_034944399.3 → XP_034800290.1  phospholipid hydroperoxide glutathione peroxidase GPX4 isoform X1

    Conserved Domains (1) summary
    cd00340
    Location:77 → 230
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
Nucleotide Protein
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