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ACTR2 actin related protein 2 [ Homo sapiens (human) ]

Gene ID: 10097, updated on 5-Apr-2020

Summary

Official Symbol
ACTR2provided by HGNC
Official Full Name
actin related protein 2provided by HGNC
Primary source
HGNC:HGNC:169
See related
Ensembl:ENSG00000138071 MIM:604221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP2
Summary
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 135.1), lymph node (RPKM 134.7) and 25 other tissues See more
Orthologs

Genomic context

See ACTR2 in Genome Data Viewer
Location:
2p14
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (65227695..65271253)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65454829..65498387)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene centrosomal protein 68 Neighboring gene RAB1A, member RAS oncogene family Neighboring gene VDAC2 pseudogene 5 Neighboring gene sprouty related EVH1 domain containing 2 Neighboring gene uncharacterized LOC105374780

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
associative learning IEA
Inferred from Electronic Annotation
more info
 
asymmetric cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
cellular response to trichostatin A IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosolic transport IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
establishment or maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 
meiotic chromosome movement towards spindle pole IEA
Inferred from Electronic Annotation
more info
 
meiotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
spindle localization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Arp2/3 protein complex TAS
Traceable Author Statement
more info
PubMed 
actin cap IEA
Inferred from Electronic Annotation
more info
 
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
invadopodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
podosome core IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin-related protein 2
Names
ARP2 actin related protein 2 homolog
actin-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005386.2NP_001005386.1  actin-related protein 2 isoform a

    See identical proteins and their annotated locations for NP_001005386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC007318, AK315205, BX491447, DC404298, W15444
    Consensus CDS
    CCDS46307.1
    UniProtKB/Swiss-Prot
    P61160
    Related
    ENSP00000367220.4, ENST00000377982.8
    Conserved Domains (1) summary
    smart00268
    Location:6393
    ACTIN; Actin
  2. NM_005722.4NP_005713.1  actin-related protein 2 isoform b

    See identical proteins and their annotated locations for NP_005713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC007318, AF006082, DC404298, W15444
    Consensus CDS
    CCDS1881.1
    UniProtKB/Swiss-Prot
    P61160
    Related
    ENSP00000260641.5, ENST00000260641.9
    Conserved Domains (1) summary
    smart00268
    Location:6388
    ACTIN; Actin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    65227695..65271253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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