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ARPC1B actin related protein 2/3 complex subunit 1B [ Homo sapiens (human) ]

Gene ID: 10095, updated on 1-Jun-2020

Summary

Official Symbol
ARPC1Bprovided by HGNC
Official Full Name
actin related protein 2/3 complex subunit 1Bprovided by HGNC
Primary source
HGNC:HGNC:704
See related
Ensembl:ENSG00000130429 MIM:604223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC41; PLTEID; p40-ARC; p41-ARC
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
Expression
Broad expression in spleen (RPKM 111.2), appendix (RPKM 92.6) and 24 other tissues See more
Orthologs

Genomic context

See ARPC1B in Genome Data Viewer
Location:
7q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99374254..99394816)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (98972298..99004226)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex subunit 1A Neighboring gene Sharpr-MPRA regulatory region 4482 Neighboring gene PDGFA associated protein 1 Neighboring gene microRNA 12119 Neighboring gene ATP5MF-PTCD1 readthrough Neighboring gene BUD31 homolog Neighboring gene pentatricopeptide repeat domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
tubulobulbar complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 1B
Names
ARP2/3 protein complex subunit p41
actin related protein 2/3 complex, subunit 1B, 41kDa
arp2/3 complex 41 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055676.1 RefSeqGene

    Range
    5056..25142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1188

mRNA and Protein(s)

  1. NM_005720.4NP_005711.1  actin-related protein 2/3 complex subunit 1B

    See identical proteins and their annotated locations for NP_005711.1

    Status: REVIEWED

    Source sequence(s)
    AU143525, BC002562, CB105406
    Consensus CDS
    CCDS5661.1
    UniProtKB/Swiss-Prot
    O15143
    UniProtKB/TrEMBL
    A4D275
    Related
    ENSP00000496599.1, ENST00000646101.2
    Conserved Domains (2) summary
    sd00039
    Location:1150
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:45264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99374254..99394816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446628.1XP_024302396.1  actin-related protein 2/3 complex subunit 1B isoform X1

    Related
    ENSP00000413173.2, ENST00000443222.6
    Conserved Domains (2) summary
    sd00039
    Location:1150
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:45264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006715826.2XP_006715889.1  actin-related protein 2/3 complex subunit 1B isoform X1

    See identical proteins and their annotated locations for XP_006715889.1

    UniProtKB/Swiss-Prot
    O15143
    UniProtKB/TrEMBL
    A4D275
    Related
    ENSP00000389631.1, ENST00000451682.5
    Conserved Domains (2) summary
    sd00039
    Location:1150
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:45264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_024446629.1XP_024302397.1  actin-related protein 2/3 complex subunit 1B isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:1150
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:45264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006715825.2XP_006715888.1  actin-related protein 2/3 complex subunit 1B isoform X1

    See identical proteins and their annotated locations for XP_006715888.1

    UniProtKB/Swiss-Prot
    O15143
    UniProtKB/TrEMBL
    A4D275
    Related
    ENSP00000494033.1, ENST00000645391.1
    Conserved Domains (2) summary
    sd00039
    Location:1150
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:45264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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