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PTK2 protein tyrosine kinase 2 [ Sarcophilus harrisii (Tasmanian devil) ]

Gene ID: 100933019, updated on 8-Mar-2024

Summary

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Gene symbol
PTK2
Gene description
protein tyrosine kinase 2
See related
Ensembl:ENSSHAG00000011092
Gene type
protein coding
RefSeq status
MODEL
Organism
Sarcophilus harrisii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
47
Annotation release Status Assembly Chr Location
103 current mSarHar1.11 (GCF_902635505.1) 1 NC_045426.1 (633682238..634050647, complement)
102 previous assembly Devil_ref v7.0 (GCF_000189315.1) 2 Unlocalized Scaffold NW_003823410.1 (794832..1160686, complement)

Chromosome 1 - NC_045426.1Genomic Context describing neighboring genes Neighboring gene argonaute RISC catalytic component 2 Neighboring gene U6 spliceosomal RNA Neighboring gene DENN domain containing 3 Neighboring gene solute carrier family 45 member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal complex assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
focal adhesion kinase 1
Names
PTK2 protein tyrosine kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sarcophilus harrisii Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSarHar1.11 Primary Assembly

Genomic

  1. NC_045426.1 Reference mSarHar1.11 Primary Assembly

    Range
    633682238..634050647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031947265.1 → XP_031803125.1  focal adhesion kinase 1 isoform X20

    UniProtKB/TrEMBL
    A0A7N4V438
    Conserved Domains (5) summary
    cd05056
    Location:535 → 799
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:1039 → 1168
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  2. XM_031947245.1 → XP_031803105.1  focal adhesion kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A7N4PYW7, G3WC11
    Related
    ENSSHAP00000012966.2, ENSSHAT00000013072.2
    Conserved Domains (5) summary
    cd05056
    Location:507 → 771
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:1011 → 1140
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  3. XM_012541848.3 → XP_012397302.2  focal adhesion kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (5) summary
    cd05056
    Location:494 → 758
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:998 → 1127
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  4. XM_031947247.1 → XP_031803107.1  focal adhesion kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (5) summary
    cd05056
    Location:501 → 765
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:1005 → 1134
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  5. XM_031947249.1 → XP_031803109.1  focal adhesion kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (5) summary
    cd05056
    Location:500 → 764
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:1001 → 1130
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  6. XM_031947248.1 → XP_031803108.1  focal adhesion kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (5) summary
    cd05056
    Location:500 → 764
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:1004 → 1133
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  7. XM_031947246.1 → XP_031803106.1  focal adhesion kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (5) summary
    cd05056
    Location:507 → 771
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:1008 → 1137
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  8. XM_031947250.1 → XP_031803110.1  focal adhesion kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (5) summary
    cd05056
    Location:494 → 758
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:995 → 1124
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  9. XM_031947254.1 → XP_031803114.1  focal adhesion kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A7N4NWM3, A0A7N4PJR4
    Related
    ENSSHAP00000039513.1, ENSSHAT00000024624.1
    Conserved Domains (5) summary
    cd05056
    Location:472 → 736
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:976 → 1105
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  10. XM_031947251.1 → XP_031803111.1  focal adhesion kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A7N4NWM3, A0A7N4PJR4
    Conserved Domains (5) summary
    cd05056
    Location:472 → 736
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:976 → 1105
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  11. XM_031947252.1 → XP_031803112.1  focal adhesion kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A7N4NWM3, A0A7N4PJR4
    Related
    ENSSHAP00000029131.1, ENSSHAT00000024990.1
    Conserved Domains (5) summary
    cd05056
    Location:472 → 736
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:976 → 1105
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  12. XM_031947256.1 → XP_031803116.1  focal adhesion kinase 1 isoform X10

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (5) summary
    cd05056
    Location:428 → 692
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1061
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  13. XM_031947255.1 → XP_031803115.1  focal adhesion kinase 1 isoform X9

    UniProtKB/TrEMBL
    A0A7N4NVD7, A0A7N4PER2
    Related
    ENSSHAP00000028540.1, ENSSHAT00000049316.1
    Conserved Domains (5) summary
    cd05056
    Location:459 → 723
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:963 → 1092
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  14. XM_031947257.1 → XP_031803117.1  focal adhesion kinase 1 isoform X11

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (4) summary
    cd05056
    Location:309 → 573
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:1 → 139
    B41; Band 4.1 homologues
    cd13190
    Location:135 → 245
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:813 → 942
    Focal_AT; Focal adhesion targeting region

  15. XM_031947260.1 → XP_031803120.1  focal adhesion kinase 1 isoform X14

    UniProtKB/TrEMBL
    A0A7N4PYW7
    Conserved Domains (4) summary
    cd05056
    Location:246 → 510
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:15 → 76
    B41; Band 4.1 homologues
    cd13190
    Location:72 → 182
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:750 → 879
    Focal_AT; Focal adhesion targeting region

  16. XM_023496523.2 → XP_023352291.1  focal adhesion kinase 1 isoform X17

    Conserved Domains (2) summary
    cd05056
    Location:7 → 271
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:511 → 640
    Focal_AT; Focal adhesion targeting region

  17. XM_031947262.1 → XP_031803122.1  focal adhesion kinase 1 isoform X16

    Conserved Domains (2) summary
    cd05056
    Location:14 → 278
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:518 → 647
    Focal_AT; Focal adhesion targeting region

  18. XM_031947263.1 → XP_031803123.1  focal adhesion kinase 1 isoform X18

    Conserved Domains (2) summary
    pfam03623
    Location:331 → 460
    Focal_AT; Focal adhesion targeting region
    cl21453
    Location:1 → 91
    PKc_like; Protein Kinases, catalytic domain

  19. XM_031947264.1 → XP_031803124.1  focal adhesion kinase 1 isoform X19

    Conserved Domains (1) summary
    pfam03623
    Location:229 → 358
    Focal_AT; Focal adhesion targeting region

  20. XM_031947259.1 → XP_031803119.1  focal adhesion kinase 1 isoform X13

    Conserved Domains (4) summary
    cd05056
    Location:507 → 771
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  21. XM_031947258.1 → XP_031803118.1  focal adhesion kinase 1 isoform X12

    Conserved Domains (4) summary
    cd05056
    Location:507 → 771
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain

  22. XM_031947261.1 → XP_031803121.1  focal adhesion kinase 1 isoform X15

    Conserved Domains (4) summary
    smart00295
    Location:115 → 337
    B41; Band 4.1 homologues
    cd13190
    Location:333 → 443
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam18038
    Location:114 → 209
    FERM_N_2; FERM N-terminal domain
    cl21453
    Location:507 → 670
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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