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SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Sarcophilus harrisii (Tasmanian devil) ]

Gene ID: 100932999, updated on 8-Mar-2024

Summary

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Gene symbol
SOS2
Gene description
SOS Ras/Rho guanine nucleotide exchange factor 2
See related
Ensembl:ENSSHAG00000003599
Gene type
protein coding
RefSeq status
MODEL
Organism
Sarcophilus harrisii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
24
Annotation release Status Assembly Chr Location
103 current mSarHar1.11 (GCF_902635505.1) 2 NC_045427.1 (339400228..339511651, complement)
102 previous assembly Devil_ref v7.0 (GCF_000189315.1) 1 Unlocalized Scaffold NW_003816565.1 (67704..179812)

Chromosome 2 - NC_045427.1Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor 6 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene distal membrane arm assembly component 2 like Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sarcophilus harrisii Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSarHar1.11 Primary Assembly

Genomic

  1. NC_045427.1 Reference mSarHar1.11 Primary Assembly

    Range
    339400228..339511651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031952969.1 → XP_031808829.1  son of sevenless homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A7N4PJB8, G3VLM7
    Related
    ENSSHAP00000004082.1, ENSSHAT00000004123.2
    Conserved Domains (5) summary
    smart00229
    Location:593 → 737
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:772 → 1011
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 381
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:70 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_031952970.1 → XP_031808830.1  son of sevenless homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A7N4P883
    Conserved Domains (4) summary
    smart00229
    Location:421 → 565
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:600 → 839
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:27 → 209
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:265 → 371
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
Nucleotide Protein
Heading Accession and Version

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