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UST uronyl 2-sulfotransferase [ Homo sapiens (human) ]

Gene ID: 10090, updated on 11-Sep-2019

Summary

Official Symbol
USTprovided by HGNC
Official Full Name
uronyl 2-sulfotransferaseprovided by HGNC
Primary source
HGNC:HGNC:17223
See related
Ensembl:ENSG00000111962 MIM:610752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2OST
Summary
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 10.7), adrenal (RPKM 4.5) and 21 other tissues See more
Orthologs

Genomic context

See UST in Genome Data Viewer
Location:
6q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (148745891..149076990)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149068063..149398126)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot D Neighboring gene Sharpr-MPRA regulatory region 590 Neighboring gene ribosomal protein SA pseudogene 40 Neighboring gene uncharacterized LOC107986659 Neighboring gene UST antisense RNA 1 Neighboring gene uncharacterized LOC105378047 Neighboring gene uncharacterized LOC105378046 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene TAB2 antisense RNA 1 Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
NHGRI GWA Catalog
Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.
NHGRI GWA Catalog
Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfotransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
dermatan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
protein sulfation TAS
Traceable Author Statement
more info
PubMed 
regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uronyl 2-sulfotransferase
Names
dermatan/chondroitin sulfate 2-sulfotransferase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005715.3NP_005706.1  uronyl 2-sulfotransferase

    See identical proteins and their annotated locations for NP_005706.1

    Status: VALIDATED

    Source sequence(s)
    AB020316, AI570697, AL807246, BC093668, CA842761, DB496757
    Consensus CDS
    CCDS5213.1
    UniProtKB/Swiss-Prot
    Q9Y2C2
    Related
    ENSP00000356433.4, ENST00000367463.5
    Conserved Domains (1) summary
    cl22970
    Location:104356
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    148745891..149076990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010152.1XP_016865641.1  uronyl 2-sulfotransferase isoform X2

  2. XM_011535378.3XP_011533680.1  uronyl 2-sulfotransferase isoform X1

    Conserved Domains (1) summary
    cl22970
    Location:104211
    Sulfotransfer_2; Sulfotransferase family

RNA

  1. XR_001743088.2 RNA Sequence

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