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UST uronyl 2-sulfotransferase [ Homo sapiens (human) ]

Gene ID: 10090, updated on 22-Sep-2022

Summary

Official Symbol
USTprovided by HGNC
Official Full Name
uronyl 2-sulfotransferaseprovided by HGNC
Primary source
HGNC:HGNC:17223
See related
Ensembl:ENSG00000111962 MIM:610752; AllianceGenome:HGNC:17223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2OST
Summary
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 10.7), adrenal (RPKM 4.5) and 21 other tissues See more
Orthologs
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Genomic context

See UST in Genome Data Viewer
Location:
6q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (148747030..149076990)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (149946826..150276839)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149068166..149398126)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 40 Neighboring gene uncharacterized LOC124901425 Neighboring gene uncharacterized LOC107986659 Neighboring gene Sharpr-MPRA regulatory region 942 Neighboring gene uncharacterized LOC124901424 Neighboring gene UST antisense RNA 1 Neighboring gene UST antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 12512 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
EBI GWAS Catalog
Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.
EBI GWAS Catalog
Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfotransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in dermatan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in protein sulfation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
uronyl 2-sulfotransferase
Names
dermatan/chondroitin sulfate 2-sulfotransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005715.3NP_005706.1  uronyl 2-sulfotransferase

    See identical proteins and their annotated locations for NP_005706.1

    Status: VALIDATED

    Source sequence(s)
    AB020316, AI570697, AL807246, BC093668, CA842761, DB496757
    Consensus CDS
    CCDS5213.1
    UniProtKB/Swiss-Prot
    B2RCX6, Q9Y2C2
    Related
    ENSP00000356433.4, ENST00000367463.5
    Conserved Domains (1) summary
    cl22970
    Location:104356
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    148747030..149076990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418047.1XP_047274003.1  uronyl 2-sulfotransferase isoform X1

  2. XM_047418048.1XP_047274004.1  uronyl 2-sulfotransferase isoform X1

  3. XM_011535378.4XP_011533680.1  uronyl 2-sulfotransferase isoform X2

    Conserved Domains (1) summary
    cl22970
    Location:104211
    Sulfotransfer_2; Sulfotransferase family
  4. XM_017010152.2XP_016865641.1  uronyl 2-sulfotransferase isoform X3

RNA

  1. XR_001743088.3 RNA Sequence

  2. XR_007059195.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    149946826..150276839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)