PTCSC3 papillary thyroid carcinoma susceptibility candidate 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTCSC3provided by HGNC
Official Full Name: papillary thyroid carcinoma susceptibility candidate 3provided by HGNC
Primary source: HGNC:HGNC:43959
See related: Ensembl:ENSG00000259104 MIM:614821; AllianceGenome:HGNC:43959
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Restricted expression toward thyroid (RPKM 7.9) See more
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Genomic context

Location:: 14q13.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (36134890..36176722, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (30323690..30365494, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (36604096..36645928, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTCSC3-mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation.
Title: PTCSC3-mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation.
LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p.
Title: LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p.
LncRNA PTCSC3 Is a Biomarker for the Treatment and Prognosis of Gastric Cancer.
Title: LncRNA PTCSC3 Is a Biomarker for the Treatment and Prognosis of Gastric Cancer.
LncRNA PTCSC3 inhibits triple-negative breast cancer cell proliferation by downregulating lncRNA H19.
Title: LncRNA PTCSC3 inhibits triple-negative breast cancer cell proliferation by downregulating lncRNA H19.
LncRNA PTCSC3 inhibits cell proliferation in laryngeal squamous cell carcinoma by down-regulating lncRNA HOTAIR.
Title: LncRNA PTCSC3 inhibits cell proliferation in laryngeal squamous cell carcinoma by down-regulating lncRNA HOTAIR.
lncRNA PTCSC3 may regulate the proliferation of periodontal ligament stem cells and TLR4 expression to improve periodontitis
Title: LncRNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) regulates the proliferation of human periodontal ligament stem cells and toll-like receptor 4 (TLR4) expression to improve periodontitis.
LncRNA PTCSC3 was low-expressed in anaplastic thyroid cancer (ATC) tissues and cells. Over-expressed PTCSC3 inhibited the drug resistance of ATC to doxorubicin. PTCSC3 negatively regulated STAT3, and STAT3 promoted expression of INO80. PTCSC3 regulated INO80 through STAT3. PTCSC3 suppressed stem cells properties and drug resistance of ATC to doxorubicin.
Title: LncRNA PTCSC3 affects drug resistance of anaplastic thyroid cancer through STAT3/INO80 pathway.
The signaling PTCSC3-miR-574-5p-SCAI-Wnt/beta-catenin mediated the proliferation and migration of PTC-1 cells, which was vital for the further papillary thyroid carcinoma therapy and prognosis.
Title: LncRNA PTCSC3/miR-574-5p Governs Cell Proliferation and Migration of Papillary Thyroid Carcinoma via Wnt/β-Catenin Signaling.
LncRNA PTCSC3 inhibits the proliferation and migration of glioma cells and suppresses Wnt/beta-catenin signaling pathway by targeting LRP6
Title: Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway.
Identify novel associations between large-vessel ischemic stroke and polymorphisms in the PTCSC3 gene.
Title: Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Variation

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General gene information

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Other Names

papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.