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PTGES3L prostaglandin E synthase 3 like [ Homo sapiens (human) ]

Gene ID: 100885848, updated on 26-Oct-2022

Summary

Official Symbol
PTGES3Lprovided by HGNC
Official Full Name
prostaglandin E synthase 3 likeprovided by HGNC
Primary source
HGNC:HGNC:43943
See related
Ensembl:ENSG00000267060 AllianceGenome:HGNC:43943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable Hsp90 protein binding activity and chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 7.5), testis (RPKM 1.6) and 9 other tissues See more
Orthologs
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Genomic context

See PTGES3L in Genome Data Viewer
Location:
17q21.31
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42968103..42980080, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43825128..43837352, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41120120..41132097, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene PTGES3L-AARSD1 readthrough Neighboring gene alanyl-tRNA synthetase domain containing 1 Neighboring gene RUN domain containing 1 Neighboring gene uncharacterized LOC124904006 Neighboring gene ribosomal protein L27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough PTGES3L-AARSD1

Readthrough gene: PTGES3L-AARSD1, Included gene: AARSD1

Homology

Clone Names

  • FLJ32403, FLJ36083

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative protein PTGES3L
Names
prostaglandin E synthase 3 (cytosolic)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142653.2NP_001136125.2  putative protein PTGES3L isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 5, resulting in an isoform (3) that is shorter than isoform 5.
    Source sequence(s)
    AC055866, BC004172, DA900052
    Consensus CDS
    CCDS45693.1
    Related
    ENSP00000404440.3, ENST00000451885.3
    Conserved Domains (1) summary
    cl00175
    Location:577
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. NM_001142654.2NP_001136126.2  putative protein PTGES3L isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 5, resulting in an isoform (4) that is shorter than isoform 5.
    Source sequence(s)
    AC055866, AK056965
    Consensus CDS
    CCDS45692.2
    UniProtKB/TrEMBL
    A0A7N4I3A5
    Related
    ENSP00000386902.4, ENST00000409446.8
    Conserved Domains (1) summary
    cl00175
    Location:472
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  3. NM_001261430.2NP_001248359.2  putative protein PTGES3L isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC055866
    Consensus CDS
    CCDS92328.1
    UniProtKB/TrEMBL
    H7C1Q7
    Related
    ENSP00000467778.2, ENST00000591916.7
    Conserved Domains (1) summary
    cd00237
    Location:5110
    p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42968103..42980080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    43825128..43837352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)