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IFNG-AS1 IFNG antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 100885789, updated on 21-Mar-2023

Summary

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Official Symbol
IFNG-AS1provided by HGNC
Official Full Name
IFNG antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:43910
See related
Ensembl:ENSG00000255733 AllianceGenome:HGNC:43910
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEST; Tmevpg1; GS1-410F4.2
Expression
Biased expression in lymph node (RPKM 3.8), appendix (RPKM 1.7) and 7 other tissues See more
Orthologs
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Genomic context

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See IFNG-AS1 in Genome Data Viewer
Location:
12q15
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (67989445..68021327)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (67968957..68000836)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68383225..68415107)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:68374855-68376054 Neighboring gene ribosomal protein L39 pseudogene 28 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 70 Neighboring gene 39S ribosomal protein L21, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma. Wang Z, et al. Bioengineered, 2021 Dec. PMID 34872454, Free PMC Article
  2. A potential marker in brucellosis, long non coding RNA IFNG-AS1. Gheitasi R, et al. Mol Biol Rep, 2019 Dec. PMID 31595441
  3. The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation. Rankin CR, et al. Am J Physiol Gastrointest Liver Physiol, 2020 Jan 1. PMID 31545920, Free PMC Article
  4. LncRNAs associated with multiple sclerosis expressed in the Th1 cell lineage. Hosseini A, et al. J Cell Physiol, 2019 Dec. PMID 31066039
  5. IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells. Stein N, et al. iScience, 2019 Jan 25. PMID 30661002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma.
    Title: Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma.
  2. Investigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever.
    Title: Investigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever.
  3. Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis.
    Title: Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis.
  4. LncRNAs encoded by AC007278.2 and IFNG-AS1-001 showed significantly higher expression in relapsing Phase multiple sclerosis patients whereas IFNG-AS1-003 was elevated in patients in the remitting phase compared with relapsing patients.
    Title: LncRNAs associated with multiple sclerosis expressed in the Th1 cell lineage.
  5. The ulcerative colitis -associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation.
    Title: The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation.
  6. The expression level of LncRNA IFNG-AS1 and IFN-gamma increased significantly in all patient groups with brucellosis compared to healthy subjects. Its effective role in many protective actions, including enhancing the expression of IFN-gamma in the immune response in brucellosis patients, suggest a new molecular interaction response to brucella infection.
    Title: A potential marker in brucellosis, long non coding RNA IFNG-AS1.
  7. These results establish Ifng-as1 as an important regulator of Ifng expression, as a DNA element and transcribed RNA, involved in dynamic and cell state-specific responses to infection.
    Title: The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.
  8. High expression of IFNG-AS1 is associated with breast cancer.
    Title: Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer.
  9. In conclusion, our findings suggested that IFNG-AS1 may function as an oncogene in pituitary adenoma by interacting with ESRP2.
    Title: Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas.
  10. we speculated that TMEVPG1 could promote IFNG transcription, and IFNG over-expression negative feedback regulated on TMEVPG1 expression, which resulted in decreased TMEVPG1 in ITP patients.
    Title: Aberrant expression of long noncoding RNA TMEVPG1 in patients with primary immune thrombocytopenia.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Other Names

  • IFNG antisense RNA 1 (non-protein coding)
  • LincR-Ifng-3'AS
  • Theiler's murine encephalomyelitis virus persistence candidate gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_104124.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC005294, AK124066, BG756823

  2. NR_104125.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC005294, AK124066
    Related
    ENST00000538665.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    67989445..68021327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    67968957..68000836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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