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LINC-ROR long intergenic non-protein coding RNA, regulator of reprogramming [ Homo sapiens (human) ]

Gene ID: 100885779, updated on 11-Jul-2021

Summary

Official Symbol
LINC-RORprovided by HGNC
Official Full Name
long intergenic non-protein coding RNA, regulator of reprogrammingprovided by HGNC
Primary source
HGNC:HGNC:43773
See related
Ensembl:ENSG00000258609 MIM:615173
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROR; lincRNA-RoR; lincRNA-ST8SIA3
Summary
This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]
Expression
Low expression observed in reference dataset See more
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Genomic context

See LINC-ROR in Genome Data Viewer
Location:
18q21.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (57054559..57072119, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (54721790..54739350, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene WDR7 overlapping transcript 1 Neighboring gene uncharacterized LOC105372136 Neighboring gene biorientation of chromosomes in cell division 1 like 2 Neighboring gene long intergenic non-protein coding RNA 2565

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_048536.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI340242, HQ315778
    Related
    ENST00000553704.3
  2. NR_152602.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB908956, AI340242, LC027886
    Related
    ENST00000645956.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    57054559..57072119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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