nfe2l2b nfe2 like bZIP transcription factor 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nfe2l2bprovided by ZNC
Official Full Name: nfe2 like bZIP transcription factor 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-120320-3
See related: Ensembl:ENSDARG00000089697 AllianceGenome:ZFIN:ZDB-GENE-120320-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nrf2b; si:dkey-3d18.4
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	6	NC_133181.1 (11847614..11875098, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (10889035..10902853, complement)

Chromosome 6 - NC_133181.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a specific role for Nrf2b as a negative regulator of several genes, including p53, cyclin G1, and heme oxygenase 1, in embryos.
Title: Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear factor erythroid 2-related factor 2b

Names: nuclear factor (erythroid-derived 2)-like 2b; nuclear factor, erythroid 2-like 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001257183.1 → NP_001244112.1 nuclear factor erythroid 2-related factor 2b

See identical proteins and their annotated locations for NP_001244112.1

Status: PROVISIONAL

Source sequence(s)

HQ661166

UniProtKB/TrEMBL

G8DKA8

Related

ENSDARP00000106581.2, ENSDART00000122221.4

Conserved Domains (1) summary

cd14720
Location:388 → 455

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133181.1 Reference GRCz12tu Primary Assembly

Range

11847614..11875098 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_073952464.1 → XP_073808565.1 nuclear factor erythroid 2-related factor 2b isoform X3
XM_073952463.1 → XP_073808564.1 nuclear factor erythroid 2-related factor 2b isoform X2
XM_073952465.1 → XP_073808566.1 nuclear factor erythroid 2-related factor 2b isoform X4
XM_068221609.1 → XP_068077710.1 nuclear factor erythroid 2-related factor 2b isoform X1

UniProtKB/TrEMBL

A0AB32TUN3
XM_073952466.1 → XP_073808567.1 nuclear factor erythroid 2-related factor 2b isoform X4