U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EPS8L2 EPS8 signaling adaptor L2 [ Canis lupus familiaris (dog) ]

Gene ID: 100856027, updated on 17-Aug-2024

Summary

Official Symbol
EPS8L2provided by VGNC
Official Full Name
EPS8 signaling adaptor L2provided by VGNC
Primary source
VGNC:VGNC:40429
See related
Ensembl:ENSCAFG00845017767
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See EPS8L2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (26347768..26364453)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (25412090..25428770)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (26114622..26131352)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (25857278..25873972)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (25502322..25518986)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene DEAF1 transcription factor Neighboring gene transmembrane protein 80 Neighboring gene uncharacterized LOC111090925 Neighboring gene transaldolase 1 Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene cell cycle exit and neuronal differentiation 1

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
epidermal growth factor receptor kinase substrate 8-like protein 2
Names
EPS8 like 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    26347768..26364453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038424043.1XP_038279971.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RDA2, A0A8C0SER6, A0A8I3S2U9
    Related
    ENSCAFP00845024646.1, ENSCAFT00845031472.1
    Conserved Domains (3) summary
    cd09540
    Location:620685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  2. XM_038424044.1XP_038279972.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SER6
    Related
    ENSCAFP00845024913.1, ENSCAFT00845031841.1
    Conserved Domains (3) summary
    cd09540
    Location:575640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    25857278..25873972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500406.1XP_038356334.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    25502322..25518986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038627085.1XP_038483013.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    Conserved Domains (3) summary
    cd09540
    Location:620685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  2. XM_038627086.1XP_038483014.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    Conserved Domains (3) summary
    cd09540
    Location:575640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    26114622..26131352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562964.1XP_038418892.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RDA2, A0A8C0SER6, A0A8I3S2U9
    Conserved Domains (3) summary
    cd09540
    Location:620685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  2. XM_038562965.1XP_038418893.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SER6
    Conserved Domains (3) summary
    cd09540
    Location:575640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25412090..25428770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038453901.1XP_038309829.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RDA2, A0A8C0SER6, A0A8I3S2U9
    Conserved Domains (3) summary
    cd09540
    Location:620685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  2. XM_038453902.1XP_038309830.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SER6
    Conserved Domains (3) summary
    cd09540
    Location:575640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain