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EPS8L2 EPS8 signaling adaptor L2 [ Canis lupus familiaris (dog) ]

Gene ID: 100856027, updated on 17-Aug-2024

Summary

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Official Symbol
EPS8L2provided by VGNC
Official Full Name
EPS8 signaling adaptor L2provided by VGNC
Primary source
VGNC:VGNC:40429
See related
Ensembl:ENSCAFG00845017767
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See EPS8L2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (26347768..26364453)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (25412090..25428770)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (26114622..26131352)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (25857278..25873972)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (25502322..25518986)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene DEAF1 transcription factor Neighboring gene transmembrane protein 80 Neighboring gene uncharacterized LOC111090925 Neighboring gene transaldolase 1 Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene cell cycle exit and neuronal differentiation 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8-like protein 2
Names
EPS8 like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    26347768..26364453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038424043.1 → XP_038279971.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RDA2, A0A8C0SER6, A0A8I3S2U9
    Related
    ENSCAFP00845024646.1, ENSCAFT00845031472.1
    Conserved Domains (3) summary
    cd09540
    Location:620 → 685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495 → 546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038424044.1 → XP_038279972.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SER6
    Related
    ENSCAFP00845024913.1, ENSCAFT00845031841.1
    Conserved Domains (3) summary
    cd09540
    Location:575 → 640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450 → 501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3 → 133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    25857278..25873972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500406.1 → XP_038356334.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    25502322..25518986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038627085.1 → XP_038483013.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    Conserved Domains (3) summary
    cd09540
    Location:620 → 685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495 → 546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038627086.1 → XP_038483014.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    Conserved Domains (3) summary
    cd09540
    Location:575 → 640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450 → 501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3 → 133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    26114622..26131352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562964.1 → XP_038418892.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RDA2, A0A8C0SER6, A0A8I3S2U9
    Conserved Domains (3) summary
    cd09540
    Location:620 → 685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495 → 546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038562965.1 → XP_038418893.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SER6
    Conserved Domains (3) summary
    cd09540
    Location:575 → 640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450 → 501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3 → 133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25412090..25428770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038453901.1 → XP_038309829.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RDA2, A0A8C0SER6, A0A8I3S2U9
    Conserved Domains (3) summary
    cd09540
    Location:620 → 685
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:495 → 546
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038453902.1 → XP_038309830.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SER6
    Conserved Domains (3) summary
    cd09540
    Location:575 → 640
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:450 → 501
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3 → 133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein
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