KIF5B kinesin family member 5B [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KIF5Bprovided by VGNC
Official Full Name: kinesin family member 5Bprovided by VGNC
Primary source: VGNC:VGNC:42408
See related: Ensembl:ENSCAFG00845009863
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (13072118..13117087)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (12323571..12368548)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (12676797..12721749)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (12512247..12557211)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (12403006..12447970)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

stable knockdown of Kif5b in MDCK cells can lead to epithelial-mesenchymal transition, which is mediated by defective E-cadherin and NMMIIA expression
Title: Stable knockdown of Kif5b in MDCK cells leads to epithelial-mesenchymal transition.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info	PubMed
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: kinesin-1 heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

13072118..13117087

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038658193.1 → XP_038514121.1 kinesin-1 heavy chain isoform X1

UniProtKB/TrEMBL

A0A8C0NXA2, A0A8C0Q0Q3, A0A8I3N413, A0A8I3NBU4

Related

ENSCAFP00845013657.1, ENSCAFT00845017547.1

Conserved Domains (3) summary

COG4372
Location:713 → 918

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

TIGR02168
Location:414 → 803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01369
Location:6 → 325

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

Alternate UMICH_Zoey_3.1

Genomic

NC_049262.1 Alternate UMICH_Zoey_3.1

Range

12512247..12557211

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038469163.1 → XP_038325091.1 kinesin-1 heavy chain isoform X1

Conserved Domains (3) summary

COG4372
Location:713 → 918

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

TIGR02168
Location:414 → 803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01369
Location:6 → 325

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049743.1 Alternate UNSW_CanFamBas_1.0

Range

12403006..12447970

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038594125.1 → XP_038450053.1 kinesin-1 heavy chain isoform X1

Conserved Domains (3) summary

COG4372
Location:713 → 918

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

TIGR02168
Location:414 → 803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01369
Location:6 → 325

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049223.1 Alternate UU_Cfam_GSD_1.0

Range

12676797..12721749

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038529873.1 → XP_038385801.1 kinesin-1 heavy chain isoform X2

UniProtKB/TrEMBL

A0A8C0Q0Q3, A0A8I3NBU4

RNA

XR_005355202.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

12323571..12368548

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003638878.5 → XP_003638926.1 kinesin-1 heavy chain isoform X1

UniProtKB/TrEMBL

A0A8C0NXA2, A0A8C0Q0Q3, A0A8I3N413, A0A8I3NBU4

Conserved Domains (3) summary

COG4372
Location:713 → 918

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

TIGR02168
Location:414 → 803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01369
Location:6 → 325

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup