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MIR5188 microRNA 5188 [ Homo sapiens (human) ]

Gene ID: 100847004, updated on 17-Sep-2024

Summary

Official Symbol
MIR5188provided by HGNC
Official Full Name
microRNA 5188provided by HGNC
Primary source
HGNC:HGNC:43502
See related
Ensembl:ENSG00000265345 miRBase:MI0018167; AllianceGenome:HGNC:43502
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-5188
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR5188 in Genome Data Viewer
Location:
12q24.31
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (124915547..124915659)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (124920755..124920867)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125400093..125400205)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 927, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9680 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125398493-125399450 Neighboring gene ubiquitin C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5068 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:125400549-125401748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:125405603-125406281 Neighboring gene tRNA-Ala (anticodon TGC) 3-2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7314 Neighboring gene tRNA-Asp (anticodon GTC) 2-9

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_049820.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC126309
    Related
    ENST00000583467.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    124915547..124915659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    124920755..124920867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)