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CDH10 cadherin 10 [ Homo sapiens (human) ]

Gene ID: 1008, updated on 8-Jul-2021

Summary

Official Symbol
CDH10provided by HGNC
Official Full Name
cadherin 10provided by HGNC
Primary source
HGNC:HGNC:1749
See related
Ensembl:ENSG00000040731 MIM:604555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]
Expression
Biased expression in brain (RPKM 13.5) and prostate (RPKM 2.1) See more
Orthologs
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Genomic context

See CDH10 in Genome Data Viewer
Location:
5p14.2-p14.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (24487100..24644978, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (24487209..24645087, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2899 Neighboring gene AKT interacting protein pseudogene Neighboring gene AKT interacting protein pseudogene Neighboring gene uncharacterized LOC105374689 Neighboring gene transient receptor potential cation channel subfamily C member 6 pseudogene Neighboring gene BTG anti-proliferation factor 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variants on 5p14.1 associate with autism spectrum disorders.
GeneReviews: Not available
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
GeneReviews: Not available
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cadherin-10
Names
T2-cadherin
cadherin 10 type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317222.2NP_001304151.1  cadherin-10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    BC144168, BM669374, DA316487, DA531048
    Conserved Domains (1) summary
    pfam01049
    Location:41188
    Cadherin_C; Cadherin cytoplasmic region
  2. NM_001317224.2NP_001304153.1  cadherin-10 isoform 3 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3, also known as CDH10_B) is shorter than isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC010387, AC091885
    UniProtKB/TrEMBL
    X5DNG6
    Conserved Domains (3) summary
    cd11304
    Location:164265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80158
    CA; Cadherin repeats
    pfam01049
    Location:633780
    Cadherin_C; Cadherin cytoplasmic region
  3. NM_001362460.1NP_001349389.1  cadherin-10 isoform 4 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1. This isoform (4) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC010387, AC091885
    Related
    ENSP00000425653.1, ENST00000510477.5
    Conserved Domains (2) summary
    cd11304
    Location:164265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80158
    CA; Cadherin repeats
  4. NM_006727.5NP_006718.2  cadherin-10 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006718.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB035303, BM669374, DA316487, DA531048
    Consensus CDS
    CCDS3892.1
    UniProtKB/Swiss-Prot
    Q9Y6N8
    UniProtKB/TrEMBL
    X5D8X5
    Related
    ENSP00000264463.4, ENST00000264463.8
    Conserved Domains (3) summary
    cd11304
    Location:164265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80158
    CA; Cadherin repeats
    pfam01049
    Location:635782
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    24487100..24644978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513923.2XP_011512225.1  cadherin-10 isoform X1

    See identical proteins and their annotated locations for XP_011512225.1

    UniProtKB/Swiss-Prot
    Q9Y6N8
    UniProtKB/TrEMBL
    X5D8X5
    Conserved Domains (3) summary
    cd11304
    Location:164265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80158
    CA; Cadherin repeats
    pfam01049
    Location:635782
    Cadherin_C; Cadherin cytoplasmic region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001190450.1: Suppressed sequence

    Description
    NM_001190450.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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