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ATP9A ATPase phospholipid transporting 9A (putative) [ Homo sapiens (human) ]

Gene ID: 10079, updated on 5-Aug-2018

Summary

Official Symbol
ATP9Aprovided by HGNC
Official Full Name
ATPase phospholipid transporting 9A (putative)provided by HGNC
Primary source
HGNC:HGNC:13540
See related
Ensembl:ENSG00000054793 MIM:609126; Vega:OTTHUMG00000032751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPIIA
Expression
Broad expression in brain (RPKM 35.7), thyroid (RPKM 11.3) and 18 other tissues See more
Orthologs

Genomic context

See ATP9A in Genome Data Viewer
Location:
20q13.2
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (51596775..51768411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (50213314..50384908, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372663 Neighboring gene nuclear factor of activated T cells 2 Neighboring gene microRNA 3194 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene spalt like transcription factor 4 Neighboring gene long intergenic non-protein coding RNA 1429

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0611

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid-translocating ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid translocation NAS
Non-traceable Author Statement
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable phospholipid-transporting ATPase IIA
Names
ATPase type IV, phospholipid-transporting (P-type),(putative)
ATPase, class II, type 9A
phospholipid-transporting ATPase IIA
NP_006036.1
XP_011526783.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006045.2NP_006036.1  probable phospholipid-transporting ATPase IIA

    See identical proteins and their annotated locations for NP_006036.1

    Status: VALIDATED

    Source sequence(s)
    AK299064, AL035684, BC110592, BF089115, HY147052
    Consensus CDS
    CCDS33489.1
    UniProtKB/Swiss-Prot
    O75110
    UniProtKB/TrEMBL
    B4DR18, Q2NLD0
    Related
    ENSP00000342481.5, OTTHUMP00000043369, ENST00000338821.5, OTTHUMT00000106494
    Conserved Domains (2) summary
    cd07541
    Location:55967
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
    cl26237
    Location:465573
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    51596775..51768411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528481.3XP_011526783.1  probable phospholipid-transporting ATPase IIA isoform X1

    See identical proteins and their annotated locations for XP_011526783.1

    Conserved Domains (6) summary
    cd01427
    Location:630780
    HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
    TIGR01652
    Location:311023
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:119315
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:477551
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:1882
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:7891017
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
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